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• W1963533150 abstract "<i>Objectives:</i> Although epilepsy may be associated with an increased risk for sudden cardiac death, its effects on Q-T intervals has not been established. <i>Methods:</i> To determine whether changes in Q-T interval duration (QT_{max c}, QT_{min c}) and dispersion (QT_{D c}) occur in epileptic patients, we retrospectively studied 40 consecutive patients (age: 36.1 ± 22.2 years) who have had a seizure disorder for 14.0 ± 12.2 years and were seen in the Epilepsy Monitoring Unit, and 60 age-matched non-epileptic controls (age: 38.0 ± 15.6 years). Q-T intervals were calculated from a single 12-lead ECG. <i>Results:</i> QT_{max c} (425 ± 30 vs. 410 ± 36 ms, p = 0.040) and QT_{D c} (63.1 ± 22.4 vs. 31.0 ± 17.2 ms, p = 0.000) were higher, and QT_{min c} (362 ± 36 vs. 379 ± 33 ms, p = 0.040) was lower in epilepsy patients. QT_{max c} was significantly correlated with disease duration (r = –0.35, p = 0.028) before, but not after age correction (r = –0.31, p = 0.053). Neither age nor reported recent seizure frequency was correlated with any repolarization index. <i>Conclusions:</i> QT_{max c} and QT_{D c} are higher in epilepsy patients as compared to control subjects. While Q-T interval appears to be related to disease duration, particularly over the early history of disease, it is unrelated to patient age or recent reported seizure frequency." @default.
• W1963533150 created "2016-06-24" @default.
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• W1963533150 date "2009-01-01" @default.
• W1963533150 modified "2023-10-17" @default.
• W1963533150 title "Cardiac Repolarization Indices in Epilepsy Patients" @default.
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• W1963533150 doi "https://doi.org/10.1159/000233236" @default.
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