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• W1963535712 abstract "Abstract The precise contribution of T‐type Ca 2+ channels in generating action potentials (APs), burst firing and intracellular Ca 2+ signals needs further elucidation. Here, we show that Ca v 3.3 channels can trigger repetitive APs, generating spontaneous membrane potential oscillations (MPOs), and a concomitant increase in the intracellular Ca 2+ concentration ([Ca 2+ ] i ) when overexpressed in NG108‐15 cells. MPOs were dependent on Ca v 3.3 channel activity given that they were recorded from a potential range of −55 to −70 mV, blocked by nickel and mibefradil, as well as by low external Ca 2+ concentration. APs of distinct duration were recorded: short APs (sAP) or prolonged APs (pAP) with a plateau potential near −40 mV. The voltage‐dependent properties of the Ca v 3.3 channels constrained the AP duration and the plateau potential was supported by sustained calcium current through Ca v 3.3 channels. The sustained current amplitude decreased when the resting holding potential was depolarized, thereby inducing a switch of AP shape from pAP to sAP. Duration of the [Ca 2+ ] i oscillations was also closely related to the shape of APs. The Ca v 3.3 window current was the oscillation trigger as shown by shifting the Ca v 3.3 window current potential range as a result of increasing the external Ca 2+ concentration, which resulted in a corresponding shift of the AP threshold. Overall, the data demonstrate that the Ca v 3.3 window current is critical in triggering intrinsic electrical and [Ca 2+ ] i oscillations. The functional expression of Ca v 3.3 channels can generate spontaneous low‐threshold calcium APs through its window current, indicating that Ca v 3.3 channels can play a primary role in pacemaker activity." @default.
• W1963535712 created "2016-06-24" @default.
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• W1963535712 date "2006-05-01" @default.
• W1963535712 modified "2023-10-10" @default.
• W1963535712 title "T-type Ca_v3.3 calcium channels produce spontaneous low-threshold action potentials and intracellular calcium oscillations" @default.
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• W1963535712 doi "https://doi.org/10.1111/j.1460-9568.2006.04761.x" @default.
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