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• W1963537915 abstract "New-borns raise limited antibody responses to most T cell-dependent antigens but little is known about neonatal T lymphocyte responses to vaccines. In this study, we compared the immune response induced by the hepatitis B vaccine in new-borns and nai;ve adults. Infants produced markedly higher serum anti-hepatitis B surface (HBs) antibody titres than adults. This was not associated with greater HBs Ag-specific Th2 cytokine responses but with lower primary IFN-gamma responses. At 1 year, the infant memory response to HBs Ag was characterised by higher Th2 responses than those of adults. We conclude that neonatal antibody and T cell responses to hepatitis B vaccine differ from those induced in adults." @default.
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• W1963537915 date "2004-01-01" @default.
• W1963537915 modified "2023-09-24" @default.
• W1963537915 title "Hepatitis B immunisation induces higher antibody and memory Th2 responses in new-borns than in adults" @default.
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• W1963537915 doi "https://doi.org/10.1016/j.vaccine.2003.07.020" @default.
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• W1963537915 hasPublicationYear "2004" @default.
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