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- W1963538698 abstract "The effect of the Krebs 2 transplantable solid carcinoma upon the cell cycle of the duodenal cryptal progenitor population has been determined by thymidine-3H uptake and radioautography. A single pulse label of tritiated thymidine was injected into each of 183 CF1 mice with a 4-day-old solid tumor. The animals were then serially killed from 15 min to 24 hr later. Data were collected from a curve describing the rate of appearance and disappearance of labelled mitoses in the tumor and duodenum. An estimate of the time intervals of G1, S, M and G2 was calculated by two different methods and compared. The turnover rate of the cryptal progenitor population from the tumor-bearing animals was found to be essentially similar to that of the control cryptal population of the non-tumor-bearing mice. The cytokinetics of the cell cycle of the Krebs 2 carcinoma is also reported. The methods described for collecting data on the turnover rate of tissues of both tumor-bearing and non-tumor-bearing animals can be utilized to determine what effect growth-promoting and growth-inhibiting agents may have on the proliferation of normal progenitor compartments while at the same time measuring the effect of such drugs on the cytokinetics of an experimental tumor." @default.
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- W1963538698 date "1968-11-15" @default.
- W1963538698 modified "2023-10-18" @default.
- W1963538698 title "Cytokinetics of the Krebs 2 carcinoma. I. Its effect on the cell population kinetics of duodenal crypt proliferation" @default.
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- W1963538698 doi "https://doi.org/10.1002/ijc.2910030616" @default.
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