Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963539721> ?p ?o ?g. }
- W1963539721 endingPage "24" @default.
- W1963539721 startingPage "15" @default.
- W1963539721 abstract "BDNF activates trkB receptors to regulate neuronal survival, differentiation, and proliferation. Mutations in the BDNF gene, altered BDNF expression, and altered trkB expression are associated with degenerative and psychiatric disorders. The full-length trkB receptor (trkB.tk(+)) undergoes autophosphorylation to activate intracellular signaling pathways. The truncated trkB receptor (trkB.t1) is abundantly expressed in the brain but lacks the catalytic tyrosine kinase domain. TrkB.t1 is a dominant-negative receptor that inhibits trkB.tk(+) signaling. While this is an important function of trkB.t1, it is only one of its many functions. TrkB.t1 sequesters and translocate BDNF, induces filopodia and neurite outgrowth, stimulates intracellular signaling cascades, regulates Rho GTPase signaling, and modifies cytoskeletal structures. TrkB.t1 is an active signaling molecule with regulatory effects on neurons and astrocytes." @default.
- W1963539721 created "2016-06-24" @default.
- W1963539721 creator A5007663211 @default.
- W1963539721 date "2012-02-01" @default.
- W1963539721 modified "2023-10-18" @default.
- W1963539721 title "Truncated TrkB: Beyond a dominant negative receptor" @default.
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