FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963551708> ?p ?o ?g. }

• W1963551708 abstract "Arterial injury has been reported to activate the mitogen-activated ERK kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathway. Pharmacological MEK inhibition was previously shown to inhibit injury-induced neointima formation in rodent models, but inhibitor compounds were administered either locally at a high dose or systemic treatment was performed over an extended period of time. Aim of this study was, therefore, to explore the efficiency of single low-dose administration of the MEK inhibitor PD98059 on neointima formation in the injured rat carotid artery. The second aim of the study was to analyse treatment effects on MEK-dependent signaling and protein expression. PD98059 (at doses of 10 and 40 nmol) was administered to the adventitia immediately after injury using Pluronic gel as drug carrier. Compared to untreated controls, PD98059 treatment (10 nmol) resulted in significant reductions of neointima-to-media ratio (by 66%) and injury-induced lumen loss (by 53%). Conversely, lumen was increased by 33% in PD98059-treated arteries. There were no significant differences between the 10 and 40 nmol treatment groups. Dual ERK1/2 phosphorylation, and also ERK1/2 protein expression, was significantly inhibited by PD98059 treatment. Expression of the transcription factor Ets-1, a nuclear target protein of ERK1/2 was significantly suppressed in PD98059-treated arteries. Attenuation of neointima formation was associated with significantly decreased expression of the proliferation marker PCNA. In contrast, we did not find biochemical evidence of increased apoptosis in PD98059-treated arteries. Our data show that the single adventitial administration of low-dose MEK inhibitor PD98059 is sufficient to suppress neointima formation in injured arteries." @default.
• W1963551708 created "2016-06-24" @default.
• W1963551708 creator A5003091088 @default.
• W1963551708 creator A5003469260 @default.
• W1963551708 creator A5006939766 @default.
• W1963551708 creator A5019798696 @default.
• W1963551708 creator A5034791705 @default.
• W1963551708 date "2009-09-01" @default.
• W1963551708 modified "2023-10-01" @default.
• W1963551708 title "Single low-dose administration of pharmacological inhibitor of mitogen-activated ERK kinase to the adventitia of the injured rat carotid artery suppresses neointima formation and inhibits nuclear ERK signaling" @default.
• W1963551708 cites W1500667430 @default.
• W1963551708 cites W1606273823 @default.
• W1963551708 cites W1961530921 @default.
• W1963551708 cites W1966846295 @default.
• W1963551708 cites W1974538333 @default.
• W1963551708 cites W1978396086 @default.
• W1963551708 cites W1979639774 @default.
• W1963551708 cites W1982085645 @default.
• W1963551708 cites W1990581298 @default.
• W1963551708 cites W1993433059 @default.
• W1963551708 cites W1994590258 @default.
• W1963551708 cites W1995983939 @default.
• W1963551708 cites W2012958068 @default.
• W1963551708 cites W2022050378 @default.
• W1963551708 cites W2027379276 @default.
• W1963551708 cites W2027945853 @default.
• W1963551708 cites W2031272027 @default.
• W1963551708 cites W2035936653 @default.
• W1963551708 cites W2049211399 @default.
• W1963551708 cites W2052750950 @default.
• W1963551708 cites W2054016731 @default.
• W1963551708 cites W2080647590 @default.
• W1963551708 cites W2086314498 @default.
• W1963551708 cites W2088711064 @default.
• W1963551708 cites W2089110202 @default.
• W1963551708 cites W2089745440 @default.
• W1963551708 cites W2099655639 @default.
• W1963551708 cites W2100949326 @default.
• W1963551708 cites W2103382643 @default.
• W1963551708 cites W2104567339 @default.
• W1963551708 cites W2109906218 @default.
• W1963551708 cites W2121515541 @default.
• W1963551708 cites W2125678486 @default.
• W1963551708 cites W2128179614 @default.
• W1963551708 cites W2128754180 @default.
• W1963551708 cites W2135996219 @default.
• W1963551708 cites W2138292652 @default.
• W1963551708 cites W2140490890 @default.
• W1963551708 cites W2152845778 @default.
• W1963551708 cites W2153571378 @default.
• W1963551708 cites W2154193687 @default.
• W1963551708 cites W2156528051 @default.
• W1963551708 cites W2166171766 @default.
• W1963551708 cites W2167229341 @default.
• W1963551708 cites W2400923294 @default.
• W1963551708 cites W56648938 @default.
• W1963551708 doi "https://doi.org/10.1016/j.ejphar.2009.06.040" @default.
• W1963551708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19576207" @default.
• W1963551708 hasPublicationYear "2009" @default.
• W1963551708 type Work @default.
• W1963551708 sameAs 1963551708 @default.
• W1963551708 citedByCount "7" @default.
• W1963551708 countsByYear W19635517082012 @default.
• W1963551708 countsByYear W19635517082015 @default.
• W1963551708 countsByYear W19635517082016 @default.
• W1963551708 countsByYear W19635517082017 @default.
• W1963551708 countsByYear W19635517082023 @default.
• W1963551708 crossrefType "journal-article" @default.
• W1963551708 hasAuthorship W1963551708A5003091088 @default.
• W1963551708 hasAuthorship W1963551708A5003469260 @default.
• W1963551708 hasAuthorship W1963551708A5006939766 @default.
• W1963551708 hasAuthorship W1963551708A5019798696 @default.
• W1963551708 hasAuthorship W1963551708A5034791705 @default.
• W1963551708 hasConcept C126322002 @default.
• W1963551708 hasConcept C134018914 @default.
• W1963551708 hasConcept C184235292 @default.
• W1963551708 hasConcept C2776716733 @default.
• W1963551708 hasConcept C2777339539 @default.
• W1963551708 hasConcept C2778283817 @default.
• W1963551708 hasConcept C2778583881 @default.
• W1963551708 hasConcept C2781249067 @default.
• W1963551708 hasConcept C57074206 @default.
• W1963551708 hasConcept C62478195 @default.
• W1963551708 hasConcept C71924100 @default.
• W1963551708 hasConcept C86803240 @default.
• W1963551708 hasConcept C95444343 @default.
• W1963551708 hasConcept C97029542 @default.
• W1963551708 hasConcept C98274493 @default.
• W1963551708 hasConceptScore W1963551708C126322002 @default.
• W1963551708 hasConceptScore W1963551708C134018914 @default.
• W1963551708 hasConceptScore W1963551708C184235292 @default.
• W1963551708 hasConceptScore W1963551708C2776716733 @default.
• W1963551708 hasConceptScore W1963551708C2777339539 @default.
• W1963551708 hasConceptScore W1963551708C2778283817 @default.
• W1963551708 hasConceptScore W1963551708C2778583881 @default.
• W1963551708 hasConceptScore W1963551708C2781249067 @default.
• W1963551708 hasConceptScore W1963551708C57074206 @default.
• W1963551708 hasConceptScore W1963551708C62478195 @default.
• W1963551708 hasConceptScore W1963551708C71924100 @default.
• W1963551708 hasConceptScore W1963551708C86803240 @default.

• next