FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963552398> ?p ?o ?g. }

• W1963552398 endingPage "52" @default.
• W1963552398 startingPage "47" @default.
• W1963552398 abstract "Hyperlipidemia is the most common form of dyslipidemia, which is the key risk factor for cardiovascular disease and stroke. The development of effective and safe drug treatments for hyperlipidemia has been proven challenging. In this study, taking advantage of the transparency of larval zebrafish, we developed a zebrafish hyperlipidemia model for drug screening and efficacy assessment. Zebrafish at 5 d.p.f (days post fertilization) were fed with 0.1% egg yolk for 48 h (hours), followed by drug treatment for 24 h or 48 h. Tested drugs were administered into the zebrafish by direct soaking. Drug effect was evaluated based on quantitative analysis of Oil Red O (ORO) in zebrafish vena caudalis. All 5 human hypolipidemic drugs (simvastatin, lovastatin, ezetimibe, bezafibrate and hyodesoxycholic acid) showed significant hypolipidemic effects (p < 0.01) in a dose-dependent manner in the zebrafish hyperlipidemia model. 'We also found a well-known Chinese tea Pu-erh tea significantly reduced lipids in this model (p < 0.001 and p < 0.01). Our results demonstrate that the zebrafish hyperlipidemia model developed and validated in this study could be used for in vivo hyperlipidemia studies and drug screening and for assessing hypolipidemic drugs with different mechanisms." @default.
• W1963552398 created "2016-06-24" @default.
• W1963552398 creator A5006788720 @default.
• W1963552398 creator A5051840800 @default.
• W1963552398 creator A5054109320 @default.
• W1963552398 creator A5061600729 @default.
• W1963552398 date "2015-03-01" @default.
• W1963552398 modified "2023-10-15" @default.
• W1963552398 title "Rapid analysis of hypolipidemic drugs in a live zebrafish assay" @default.
• W1963552398 cites W1555460575 @default.
• W1963552398 cites W1926509225 @default.
• W1963552398 cites W1966599364 @default.
• W1963552398 cites W1981239255 @default.
• W1963552398 cites W1996904509 @default.
• W1963552398 cites W1999108312 @default.
• W1963552398 cites W2000871541 @default.
• W1963552398 cites W2012385451 @default.
• W1963552398 cites W2013768888 @default.
• W1963552398 cites W2016106077 @default.
• W1963552398 cites W2023899667 @default.
• W1963552398 cites W2040423008 @default.
• W1963552398 cites W2040693319 @default.
• W1963552398 cites W2052078289 @default.
• W1963552398 cites W2055243017 @default.
• W1963552398 cites W2066466053 @default.
• W1963552398 cites W2073119213 @default.
• W1963552398 cites W2075224548 @default.
• W1963552398 cites W2075915084 @default.
• W1963552398 cites W2076133248 @default.
• W1963552398 cites W2078180186 @default.
• W1963552398 cites W2084043096 @default.
• W1963552398 cites W2091366888 @default.
• W1963552398 cites W2099643598 @default.
• W1963552398 cites W2125349610 @default.
• W1963552398 cites W2148621802 @default.
• W1963552398 cites W2160505438 @default.
• W1963552398 cites W2322492973 @default.
• W1963552398 cites W2326667102 @default.
• W1963552398 doi "https://doi.org/10.1016/j.vascn.2014.12.002" @default.
• W1963552398 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25497901" @default.
• W1963552398 hasPublicationYear "2015" @default.
• W1963552398 type Work @default.
• W1963552398 sameAs 1963552398 @default.
• W1963552398 citedByCount "39" @default.
• W1963552398 countsByYear W19635523982016 @default.
• W1963552398 countsByYear W19635523982017 @default.
• W1963552398 countsByYear W19635523982018 @default.
• W1963552398 countsByYear W19635523982019 @default.
• W1963552398 countsByYear W19635523982020 @default.
• W1963552398 countsByYear W19635523982021 @default.
• W1963552398 countsByYear W19635523982022 @default.
• W1963552398 countsByYear W19635523982023 @default.
• W1963552398 crossrefType "journal-article" @default.
• W1963552398 hasAuthorship W1963552398A5006788720 @default.
• W1963552398 hasAuthorship W1963552398A5051840800 @default.
• W1963552398 hasAuthorship W1963552398A5054109320 @default.
• W1963552398 hasAuthorship W1963552398A5061600729 @default.
• W1963552398 hasConcept C104317684 @default.
• W1963552398 hasConcept C126322002 @default.
• W1963552398 hasConcept C134018914 @default.
• W1963552398 hasConcept C150903083 @default.
• W1963552398 hasConcept C185592680 @default.
• W1963552398 hasConcept C207001950 @default.
• W1963552398 hasConcept C2776329913 @default.
• W1963552398 hasConcept C2776839432 @default.
• W1963552398 hasConcept C2776878037 @default.
• W1963552398 hasConcept C2778096610 @default.
• W1963552398 hasConcept C2778163477 @default.
• W1963552398 hasConcept C2778657065 @default.
• W1963552398 hasConcept C2779091943 @default.
• W1963552398 hasConcept C2779134260 @default.
• W1963552398 hasConcept C2780035454 @default.
• W1963552398 hasConcept C2780940807 @default.
• W1963552398 hasConcept C55493867 @default.
• W1963552398 hasConcept C555293320 @default.
• W1963552398 hasConcept C71924100 @default.
• W1963552398 hasConcept C86803240 @default.
• W1963552398 hasConcept C98274493 @default.
• W1963552398 hasConceptScore W1963552398C104317684 @default.
• W1963552398 hasConceptScore W1963552398C126322002 @default.
• W1963552398 hasConceptScore W1963552398C134018914 @default.
• W1963552398 hasConceptScore W1963552398C150903083 @default.
• W1963552398 hasConceptScore W1963552398C185592680 @default.
• W1963552398 hasConceptScore W1963552398C207001950 @default.
• W1963552398 hasConceptScore W1963552398C2776329913 @default.
• W1963552398 hasConceptScore W1963552398C2776839432 @default.
• W1963552398 hasConceptScore W1963552398C2776878037 @default.
• W1963552398 hasConceptScore W1963552398C2778096610 @default.
• W1963552398 hasConceptScore W1963552398C2778163477 @default.
• W1963552398 hasConceptScore W1963552398C2778657065 @default.
• W1963552398 hasConceptScore W1963552398C2779091943 @default.
• W1963552398 hasConceptScore W1963552398C2779134260 @default.
• W1963552398 hasConceptScore W1963552398C2780035454 @default.
• W1963552398 hasConceptScore W1963552398C2780940807 @default.
• W1963552398 hasConceptScore W1963552398C55493867 @default.
• W1963552398 hasConceptScore W1963552398C555293320 @default.
• W1963552398 hasConceptScore W1963552398C71924100 @default.
• W1963552398 hasConceptScore W1963552398C86803240 @default.

• next