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- W1963553146 abstract "The effects of fluoride and insulin-like growth factor (IGF)-I on sodium-dependent (Nad) alanine and phosphate (Pi) transport were compared in a human osteosarcoma cell line, SAOS-2/B-10. Fluoride stimulated Nad alanine but not Pi uptake in a dose-dependent manner, whereas IGF-I stimulated both alanine and NadPi transport. IGF-I and low concentrations of fluoride stimulated Nad alanine transport rapidly. Genistein, an inhibitor of tyrosine kinase blocked IGF-I- but not fluoride-stimulated Nad alanine transport. The effects of fluoride and IGF-I were additive and not associated with corresponding changes in cell number or protein content. In conclusion, low concentrations of fluoride rapidly and selectively stimulate Nad alanine transport in SAOS-2 cells." @default.
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- W1963553146 date "1998-02-01" @default.
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- W1963553146 title "Differential effects of fluoride and insulin-like growth factor I on sodium-dependent alanine and phosphate transport in a human osteoblast-like cell line" @default.
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- W1963553146 doi "https://doi.org/10.1016/s1096-6374(98)80322-5" @default.
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