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- W1963554421 abstract "A system designed to detect plasma cells that produce antibodies directed at autologous idiotypic determinants of anti-human serum albumin (HSA) antibodies in rabbits was used to determine whether anti-HSA antibodies of horse, goat, swine and chicken origin were cross-reactive with rabbit antibodies of the same specificity. Fluorochrome-tagged anti-HSA preparations of these diverse species were used to stain splenic plasma cells of HSA-immunized rabbits and a similarly immunized chicken. The degree of idiotypic cross-reactivity, as detected by binding of anti-HSA antibodies to anti-idiotype within plasma cells of HSA-immunized animals, was sometimes equal to autologous staining. However chicken anti-Has, the most phylogenetically distant idiotype examined, was demonstrably less cross-reactive than that obtained from the other species. Likewise, chicken plasma cells usually did not bind mammalian anti-HSA antibodies to an appreciable degree, as compared with autologous staining. These findings provide evidence for serologic and possibly structural similarities of antibodies of the same specificity from different species." @default.
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- W1963554421 date "1981-07-01" @default.
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- W1963554421 title "Shared Idiotypes Among Anti-Albumin Antibodies of Different Species" @default.
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- W1963554421 doi "https://doi.org/10.1111/j.1365-3083.1981.tb00181.x" @default.
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