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• W1963554810 abstract "During deep sleep and anesthesia, the EEG of humans and animals exhibits a distinctive slow (<1 Hz) rhythm. In inhibitory neurons of the nucleus reticularis thalami (NRT), this rhythm is reflected as a slow (<1 Hz) oscillation of the membrane potential comprising stereotypical, recurring “up” and “down” states. Here we show that reducing the leak current through the activation of group I metabotropic glutamate receptors (mGluRs) with either trans -ACPD [(+/−)-1-aminocyclopentane- trans -1,3-dicarboxylic acid] (50–100 μ m ) or DHPG [( S )-3,5-dihydroxyphenylglycine] (100 μ m ) instates an intrinsic slow oscillation in NRT neurons in vitro that is qualitatively equivalent to that observed in vivo . A slow oscillation could also be evoked by synaptically activating mGluRs on NRT neurons via the tetanic stimulation of corticothalamic fibers. Through a combination of experiments and computational modeling we show that the up state of the slow oscillation is predominantly generated by the “window” component of the T-type Ca 2+ current, with an additional supportive role for a Ca 2+ -activated nonselective cation current. The slow oscillation is also fundamentally reliant on an I h current and is extensively shaped by both Ca 2+ - and Na + -activated K + currents. In combination with previous work in thalamocortical neurons, this study suggests that the thalamus plays an important and active role in shaping the slow (<1 Hz) rhythm during deep sleep." @default.
• W1963554810 created "2016-06-24" @default.
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• W1963554810 date "2006-03-01" @default.
• W1963554810 modified "2023-10-16" @default.
• W1963554810 title "Neuronal Basis of the Slow (<1 Hz) Oscillation in Neurons of the Nucleus Reticularis Thalami<i>In Vitro</i>" @default.
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• W1963554810 doi "https://doi.org/10.1523/jneurosci.3607-05.2006" @default.
• W1963554810 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6793657" @default.
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