FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963556811> ?p ?o ?g. }

• W1963556811 endingPage "2323" @default.
• W1963556811 startingPage "2313" @default.
• W1963556811 abstract "Contactins are modular extracellular cell matrix proteins that are present in the brain, and they are responsible for the proper development and functioning of neurons. They contain six immunoglobulin-like IgC2 domains and four fibronectin type III repeats. The interactions of contactin with other proteins are poorly understood. The mechanical properties of all IgC2 domains of human contactin 4 were studied using a steered molecular dynamics approach and CHARMM force field with an explicit TIP3P water environment on a 10-ns timescale. Force spectra of all domains were determined computationally and the nanomechanical unfolding process is described. The domains show different mechanical stabilities. The calculated maxima of the unfolding force are in the range of 900–1700 pN at a loading rate of 7 N/s. Our data indicate that critical regions of IgC2 domains 2 and 3, which are responsible for interactions with tyrosine phosphatases and are important in nervous system development, are affected by even weak mechanical stretching. Thus, tensions present in the cell may modulate cellular activities related to contactin function. The present data should facilitate the interpretation of atomic force microscope single-molecule spectra of numerous proteins with similar IgC2 motives." @default.
• W1963556811 created "2016-06-24" @default.
• W1963556811 creator A5013507346 @default.
• W1963556811 creator A5026272556 @default.
• W1963556811 creator A5054152314 @default.
• W1963556811 date "2011-03-29" @default.
• W1963556811 modified "2023-09-27" @default.
• W1963556811 title "Nanomechanics of Ig-like domains of human contactin (BIG-2)" @default.
• W1963556811 cites W1969189206 @default.
• W1963556811 cites W1973038704 @default.
• W1963556811 cites W1973342584 @default.
• W1963556811 cites W1976499671 @default.
• W1963556811 cites W1985876982 @default.
• W1963556811 cites W2005786312 @default.
• W1963556811 cites W2013153062 @default.
• W1963556811 cites W2015642465 @default.
• W1963556811 cites W2019877102 @default.
• W1963556811 cites W2020389898 @default.
• W1963556811 cites W2020883952 @default.
• W1963556811 cites W2027408247 @default.
• W1963556811 cites W2029667189 @default.
• W1963556811 cites W2037170319 @default.
• W1963556811 cites W2039761340 @default.
• W1963556811 cites W2049657925 @default.
• W1963556811 cites W2050495774 @default.
• W1963556811 cites W2051861976 @default.
• W1963556811 cites W2054784160 @default.
• W1963556811 cites W2060809301 @default.
• W1963556811 cites W2069099904 @default.
• W1963556811 cites W2073062083 @default.
• W1963556811 cites W2080537538 @default.
• W1963556811 cites W2088716212 @default.
• W1963556811 cites W2096490315 @default.
• W1963556811 cites W2098719726 @default.
• W1963556811 cites W2105614327 @default.
• W1963556811 cites W2118200955 @default.
• W1963556811 cites W2120772351 @default.
• W1963556811 cites W2135131430 @default.
• W1963556811 cites W2136182841 @default.
• W1963556811 cites W2138595025 @default.
• W1963556811 cites W2147749191 @default.
• W1963556811 cites W2150981663 @default.
• W1963556811 cites W2152301430 @default.
• W1963556811 cites W2157147573 @default.
• W1963556811 cites W2158238509 @default.
• W1963556811 cites W2161678210 @default.
• W1963556811 cites W2166842453 @default.
• W1963556811 doi "https://doi.org/10.1007/s00894-011-1010-y" @default.
• W1963556811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3168757" @default.
• W1963556811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21445711" @default.
• W1963556811 hasPublicationYear "2011" @default.
• W1963556811 type Work @default.
• W1963556811 sameAs 1963556811 @default.
• W1963556811 citedByCount "9" @default.
• W1963556811 countsByYear W19635568112012 @default.
• W1963556811 countsByYear W19635568112013 @default.
• W1963556811 countsByYear W19635568112014 @default.
• W1963556811 countsByYear W19635568112016 @default.
• W1963556811 countsByYear W19635568112017 @default.
• W1963556811 countsByYear W19635568112021 @default.
• W1963556811 crossrefType "journal-article" @default.
• W1963556811 hasAuthorship W1963556811A5013507346 @default.
• W1963556811 hasAuthorship W1963556811A5026272556 @default.
• W1963556811 hasAuthorship W1963556811A5054152314 @default.
• W1963556811 hasBestOaLocation W19635568111 @default.
• W1963556811 hasConcept C102951782 @default.
• W1963556811 hasConcept C12554922 @default.
• W1963556811 hasConcept C133267278 @default.
• W1963556811 hasConcept C147597530 @default.
• W1963556811 hasConcept C171250308 @default.
• W1963556811 hasConcept C185592680 @default.
• W1963556811 hasConcept C189165786 @default.
• W1963556811 hasConcept C192562407 @default.
• W1963556811 hasConcept C2776165026 @default.
• W1963556811 hasConcept C55493867 @default.
• W1963556811 hasConcept C59593255 @default.
• W1963556811 hasConcept C8010536 @default.
• W1963556811 hasConcept C85528070 @default.
• W1963556811 hasConcept C86492073 @default.
• W1963556811 hasConcept C86803240 @default.
• W1963556811 hasConceptScore W1963556811C102951782 @default.
• W1963556811 hasConceptScore W1963556811C12554922 @default.
• W1963556811 hasConceptScore W1963556811C133267278 @default.
• W1963556811 hasConceptScore W1963556811C147597530 @default.
• W1963556811 hasConceptScore W1963556811C171250308 @default.
• W1963556811 hasConceptScore W1963556811C185592680 @default.
• W1963556811 hasConceptScore W1963556811C189165786 @default.
• W1963556811 hasConceptScore W1963556811C192562407 @default.
• W1963556811 hasConceptScore W1963556811C2776165026 @default.
• W1963556811 hasConceptScore W1963556811C55493867 @default.
• W1963556811 hasConceptScore W1963556811C59593255 @default.
• W1963556811 hasConceptScore W1963556811C8010536 @default.
• W1963556811 hasConceptScore W1963556811C85528070 @default.
• W1963556811 hasConceptScore W1963556811C86492073 @default.
• W1963556811 hasConceptScore W1963556811C86803240 @default.
• W1963556811 hasIssue "9" @default.
• W1963556811 hasLocation W19635568111 @default.
• W1963556811 hasLocation W19635568112 @default.

• next