FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963559255> ?p ?o ?g. }

• W1963559255 endingPage "8864" @default.
• W1963559255 startingPage "8855" @default.
• W1963559255 abstract "Wrapping of the myelin sheath around axons by oligodendrocytes is critical for the rapid conduction of electrical signals required for the normal functioning of the CNS. Myelination is a multistep process where oligodendrocytes progress through a well coordinated differentiation program regulated by multiple extracellular growth and differentiation signals. The intracellular transduction of the extracellular signals that regulate myelination is poorly understood. Here we demonstrate a critical role for two important signaling molecules, extracelluar signal-regulated protein kinases 1 and 2 (ERK1/ERK2), downstream mediators of mitogen-activated protein kinases, in the control of CNS myelin thickness. We generated and analyzed two lines of mice lacking both ERK1/ERK2 function specifically in oligodendrocyte-lineage cells. In the absence of ERK1/ERK2 signaling NG2⁺ oligodendrocyte progenitor cells proliferated and differentiated on schedule. Mutant oligodendrocytes also ensheathed axons normally and made a few wraps of compact myelin. However, the subsequent increase in myelination that correlated myelin thickness in proportion to the axon caliber failed to occur. Furthermore, although the numbers of differentiated oligodendrocytes in the adult mutants were unchanged, they showed an inability to upregulate the transcription of major myelin genes that normally occurs during active myelination. Similarly, in vitro ERK1/ERK2-deficient oligodendrocytes differentiated normally but failed to form typical myelin-like membrane sheets. None of these effects were observed in single ERK1 or ERK2 mutants. These studies suggest that the predominant role of ERK1/ERK2 signaling in vivo is in promoting rapid myelin growth to increase its thickness, subsequent to oligodendrocyte differentiation and the initiation of myelination." @default.
• W1963559255 created "2016-06-24" @default.
• W1963559255 creator A5001689728 @default.
• W1963559255 creator A5007814757 @default.
• W1963559255 creator A5014160948 @default.
• W1963559255 creator A5030332501 @default.
• W1963559255 creator A5086871589 @default.
• W1963559255 date "2012-06-27" @default.
• W1963559255 modified "2023-10-12" @default.
• W1963559255 title "ERK1/ERK2 MAPK Signaling is Required to Increase Myelin Thickness Independent of Oligodendrocyte Differentiation and Initiation of Myelination" @default.
• W1963559255 cites W1552267233 @default.
• W1963559255 cites W1608081470 @default.
• W1963559255 cites W1837402303 @default.
• W1963559255 cites W1936899358 @default.
• W1963559255 cites W1970510801 @default.
• W1963559255 cites W1970719411 @default.
• W1963559255 cites W1979953624 @default.
• W1963559255 cites W1986536395 @default.
• W1963559255 cites W1988294221 @default.
• W1963559255 cites W1989430490 @default.
• W1963559255 cites W1989439339 @default.
• W1963559255 cites W1996798743 @default.
• W1963559255 cites W2000485285 @default.
• W1963559255 cites W2001182200 @default.
• W1963559255 cites W2001810970 @default.
• W1963559255 cites W2001888569 @default.
• W1963559255 cites W2016131601 @default.
• W1963559255 cites W2017042997 @default.
• W1963559255 cites W2025008591 @default.
• W1963559255 cites W2026491562 @default.
• W1963559255 cites W2031052253 @default.
• W1963559255 cites W2031155687 @default.
• W1963559255 cites W2035074539 @default.
• W1963559255 cites W2035916425 @default.
• W1963559255 cites W2037908014 @default.
• W1963559255 cites W2038757125 @default.
• W1963559255 cites W2039547640 @default.
• W1963559255 cites W2042528531 @default.
• W1963559255 cites W2048660379 @default.
• W1963559255 cites W2054245229 @default.
• W1963559255 cites W2055526424 @default.
• W1963559255 cites W2056575007 @default.
• W1963559255 cites W2059210704 @default.
• W1963559255 cites W2063919481 @default.
• W1963559255 cites W2064595948 @default.
• W1963559255 cites W2064847637 @default.
• W1963559255 cites W2069002586 @default.
• W1963559255 cites W2070640008 @default.
• W1963559255 cites W2070800078 @default.
• W1963559255 cites W2076682664 @default.
• W1963559255 cites W2078630298 @default.
• W1963559255 cites W2080376521 @default.
• W1963559255 cites W2089360377 @default.
• W1963559255 cites W2091439778 @default.
• W1963559255 cites W2103279601 @default.
• W1963559255 cites W2116342189 @default.
• W1963559255 cites W2124421908 @default.
• W1963559255 cites W2125650861 @default.
• W1963559255 cites W2126629775 @default.
• W1963559255 cites W2127621191 @default.
• W1963559255 cites W2128351119 @default.
• W1963559255 cites W2137165110 @default.
• W1963559255 cites W2140884992 @default.
• W1963559255 cites W2142745956 @default.
• W1963559255 cites W2147158502 @default.
• W1963559255 cites W2147893091 @default.
• W1963559255 cites W2151838519 @default.
• W1963559255 cites W2152968526 @default.
• W1963559255 cites W2331692240 @default.
• W1963559255 doi "https://doi.org/10.1523/jneurosci.0137-12.2012" @default.
• W1963559255 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3521511" @default.
• W1963559255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22745486" @default.
• W1963559255 hasPublicationYear "2012" @default.
• W1963559255 type Work @default.
• W1963559255 sameAs 1963559255 @default.
• W1963559255 citedByCount "171" @default.
• W1963559255 countsByYear W19635592552012 @default.
• W1963559255 countsByYear W19635592552013 @default.
• W1963559255 countsByYear W19635592552014 @default.
• W1963559255 countsByYear W19635592552015 @default.
• W1963559255 countsByYear W19635592552016 @default.
• W1963559255 countsByYear W19635592552017 @default.
• W1963559255 countsByYear W19635592552018 @default.
• W1963559255 countsByYear W19635592552019 @default.
• W1963559255 countsByYear W19635592552020 @default.
• W1963559255 countsByYear W19635592552021 @default.
• W1963559255 countsByYear W19635592552022 @default.
• W1963559255 countsByYear W19635592552023 @default.
• W1963559255 crossrefType "journal-article" @default.
• W1963559255 hasAuthorship W1963559255A5001689728 @default.
• W1963559255 hasAuthorship W1963559255A5007814757 @default.
• W1963559255 hasAuthorship W1963559255A5014160948 @default.
• W1963559255 hasAuthorship W1963559255A5030332501 @default.
• W1963559255 hasAuthorship W1963559255A5086871589 @default.
• W1963559255 hasBestOaLocation W19635592551 @default.
• W1963559255 hasConcept C169760540 @default.
• W1963559255 hasConcept C184235292 @default.
• W1963559255 hasConcept C2776985911 @default.

• next