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- W1963564604 abstract "1135 We examined the effects of changes in physical activity (PA) on markers of blood coagulation and fibrinolysis in 108 adults in the Seasonal Variation of Cholesterol Study [56% men, age=49±12.5 yrs, BMI=27.3±4.6 kg·m−2 (mean±SD)]. Fasting morning blood samples and PA measures were collected at baseline and then every 3 months for 1 year. Three 24-hour PA recalls were obtained at each assessment point to estimate total (TA), household (HA), occupational (OA), and leisure-time activity (LA) in MET-hrs·d−1. Baseline values of fibrinogen (FIBR), factor VIIc activity (FVIIc), and unbound plasminogen activator inhibitor-1 (PAI-1) were (mean ±SD); 306±83 mg·dl−1, 107±22%, and 55±43 ng·ml−1, respectively. Random effects models quantifying the slope (b) of the relationship between change in PA and change in FIBR, PAI-1, and FVIIc revealed that subjects reporting increases in TA had reductions in FIBR [b(men)=−0.65, (−1.7, 0.4); b(women)=−2.51, (−4.4, −0.6); (b, (95%CI)]. Increased LA was also associated with favorable reductions of FIBR in both men [b= −1.97, (−4.8, 0.4)] and women [b=−1.84, (−5.0, 1.3)]. In women only, increased OA and HA were associated with reduced FIBR levels [b=−2.05, (−5.8, 1.7) and b=−3.05, (−5.6, −0.5), respectively]. No associations were observed between any PA measure and PAI-1 or FVIIc. In conclusion, increased PA at home, at work, and during leisure-time may lower risk of cardiovascular events by favorably reducing basal levels of FIBR. Support: ACSM Fellowship for Epidemiological Research and NIH ROI HL-52745." @default.
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- W1963564604 date "1999-05-01" @default.
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- W1963564604 title "EFFECT OF CHANGES IN PHYSICAL ACTIVITY ON MARKERS OF BLOOD COAGULATION AND FIBRINOLYSIS" @default.
- W1963564604 doi "https://doi.org/10.1097/00005768-199905001-01132" @default.
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