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• W1963565087 abstract "Although the accumulation of intracellular calcium ions ([Ca 2+ ] i ) is associated with muscle damage, little is known regarding the temporal profile of muscle [Ca 2+ ] i under in vivo conditions, and, specifically, the effects of different contraction types [e.g., isometric (ISO); eccentric (ECC)] on [Ca 2+ ] i remain to be determined. The following hypotheses were tested. 1) For 90 min at rest, an in vivo vs. in vitro preparation would better maintain initial [Ca 2+ ] i . 2) Compared with ISO, ECC contractions (50 contractions, 10 sets, 5-min interval) would lead to a greater increase of [Ca 2+ ] i . 3) Elevated [Ca 2+ ] i during ECC would be reduced or prevented by the stretch-activated ion channel blockers streptomycin and gadolinium (Gd 3+ ). Spinotrapezius muscles of Wistar rats were exteriorized (in vivo) or excised (in vitro). [Ca 2+ ] i was evaluated by loading the muscle with fura 2-AM using fluorescence imaging. [Ca 2+ ] i rose progressively beyond 40 min at rest under in vitro but not in vivo conditions during the 90-min protocol. In vivo [Ca 2+ ] i increased more rapidly during ECC (first set) than ISO (fifth set) ( P < 0.05 vs. precontraction values). The peak level of [Ca 2+ ] i was increased by 21.5% (ISO) and 42.8% (ECC) after 10 sets (both P < 0.01). Streptomycin and Gd 3+ abolished the majority of [Ca 2+ ] i increase during ECC (69 and 86% reduction, respectively; P < 0.01 from peak [Ca 2+ ] i of ECC). In conclusion, in vivo quantitative analyses demonstrated that ECC contractions elevate [Ca 2+ ] i significantly more than ISO contractions and that stretch-activated channels may play a permissive role in this response." @default.
• W1963565087 created "2016-06-24" @default.
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• W1963565087 date "2008-04-01" @default.
• W1963565087 modified "2023-10-09" @default.
• W1963565087 title "Intracellular calcium accumulation following eccentric contractions in rat skeletal muscle in vivo: role of stretch-activated channels" @default.
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• W1963565087 doi "https://doi.org/10.1152/ajpregu.00815.2007" @default.
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