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- W1963568662 abstract "Abstract Rationale To compare the bronchodilator response to albuterol after a standard exercise challenge in patients receiving montelukast (M) or salmeterol (S) added to low-dose fluticasone (F). Methods Randomized, double-blind multicenter study. Patients with asthma (N=91, ages 15–60) receiving F (110 μg twice daily) who remained symptomatic and had a history of exercise-induced bronchoconstriction (EIB) were randomized to addition of M (10 mg) or S (42 μg BID) for 4 weeks. At weeks 1 and 4, patients exercised on a treadmill for 6 minutes at near-maximum heart rate; at 15 and 45 minutes after exercise, patients received 180 μg albuterol by inhalation. Serial spirometry was performed both before and after albuterol administration. FEV1 was expressed as the percent change from pre-exercise baseline. Results Baseline pre-exercise FEV1 percent predicted was 81.3 ± 1.5% in the M+F group and 78.9 ± 1.7% in the S+F group. Before treatment, patients in both groups had a significant increase in FEV1 in response to post-exercise albuterol (M+F: 11.9 ± 1.2%; S+F: 14.5 ± 1.6%). After 4 weeks, only S+F perceptibly improved pre-exercise FEV1 (7.5 ± 1.1% versus 2.1 ± 1.1%, p Conclusions The rescue response to albuterol after EIB in patients taking fluticasone is preserved with addition of montelukast but is significantly diminished with addition of salmeterol." @default.
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- W1963568662 date "2004-02-01" @default.
- W1963568662 modified "2023-09-27" @default.
- W1963568662 title "Post-exercise response to albuterol after addition of montelukast or salmeterol to inhaled fluticasone*1" @default.
- W1963568662 doi "https://doi.org/10.1016/j.jaci.2003.12.078" @default.
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