FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963570357> ?p ?o ?g. }

• W1963570357 endingPage "198" @default.
• W1963570357 startingPage "187" @default.
• W1963570357 abstract "The anticancer agent irinotecan (CPT-11) is a prodrug converted to its active form, SN-38, by human carboxylesterase (hCE) and the SN-38 is further metabolized to its inactive form, SN-38G. We investigated the expression of hCE in human lung cancer cells as well as the ability of these cells to convert CPT-11 to SN-38 using surgically resected tumor samples and cultured cell lines. SN-38 was 40- to 3,000-fold more toxic to lung cancer cell lines than CPT-11, which acted more time-dependently than SN-38. Although human lung cancer cells expressed hCE in the cytoplasm, hCE expression levels in cancer cells were not correlated with their drug sensitivities. Although intracellular CPT-11 and SN-38 levels continuously increased within 60 min of CPT-11 exposure, SN-38 levels in cells exposed to SN-38 decreased. Cells with the ability to metabolize SN-38 to SN-38G were more resistant to extracellular SN-38 than cells lacking the ability. Of 25 squamous cell carcinomas, 15 were strongly positive for hCE and six were negative. Of 25 adenocarcinomas, four were strongly positive for hCE and 16 were positive, while five were negative. Thus, 70% of non-small cell lung cancers expressed hCE. From these results, we conclude that human lung cancer cells expressed the enzyme which can convert CPT-11 to SN-38 and that intracellular SN-38 converted from CPT-11 may act as a chemotherapeutic agent together with SN-38 absorbed from the outside and augment the dose intensity of SN-38. Therefore, to assess the effects of CPT-11 prior to chemotherapy, it is important to check if lung cancer cells express hCE." @default.
• W1963570357 created "2016-06-24" @default.
• W1963570357 creator A5009338710 @default.
• W1963570357 creator A5014521829 @default.
• W1963570357 creator A5025952630 @default.
• W1963570357 creator A5034104691 @default.
• W1963570357 creator A5035593148 @default.
• W1963570357 creator A5075914998 @default.
• W1963570357 creator A5076791897 @default.
• W1963570357 creator A5078467458 @default.
• W1963570357 date "2003-08-01" @default.
• W1963570357 modified "2023-09-30" @default.
• W1963570357 title "Intracellular conversion of irinotecan to its active form, SN-38, by native carboxylesterase in human non-small cell lung cancer" @default.
• W1963570357 cites W1868251026 @default.
• W1963570357 cites W1897082568 @default.
• W1963570357 cites W1952431753 @default.
• W1963570357 cites W1964677552 @default.
• W1963570357 cites W1966419086 @default.
• W1963570357 cites W1973964757 @default.
• W1963570357 cites W1983820813 @default.
• W1963570357 cites W1984305079 @default.
• W1963570357 cites W1999506028 @default.
• W1963570357 cites W2009387119 @default.
• W1963570357 cites W2016722642 @default.
• W1963570357 cites W2021622287 @default.
• W1963570357 cites W2031436799 @default.
• W1963570357 cites W2032669985 @default.
• W1963570357 cites W2048593969 @default.
• W1963570357 cites W2059224614 @default.
• W1963570357 cites W2066978733 @default.
• W1963570357 cites W2067173591 @default.
• W1963570357 cites W2087830545 @default.
• W1963570357 cites W2100837269 @default.
• W1963570357 cites W2101108802 @default.
• W1963570357 cites W2121960395 @default.
• W1963570357 cites W2314205992 @default.
• W1963570357 cites W2317936438 @default.
• W1963570357 cites W2324886883 @default.
• W1963570357 cites W2328209945 @default.
• W1963570357 doi "https://doi.org/10.1016/s0169-5002(03)00223-x" @default.
• W1963570357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12871782" @default.
• W1963570357 hasPublicationYear "2003" @default.
• W1963570357 type Work @default.
• W1963570357 sameAs 1963570357 @default.
• W1963570357 citedByCount "56" @default.
• W1963570357 countsByYear W19635703572012 @default.
• W1963570357 countsByYear W19635703572013 @default.
• W1963570357 countsByYear W19635703572014 @default.
• W1963570357 countsByYear W19635703572015 @default.
• W1963570357 countsByYear W19635703572016 @default.
• W1963570357 countsByYear W19635703572017 @default.
• W1963570357 countsByYear W19635703572018 @default.
• W1963570357 countsByYear W19635703572019 @default.
• W1963570357 countsByYear W19635703572020 @default.
• W1963570357 countsByYear W19635703572021 @default.
• W1963570357 countsByYear W19635703572022 @default.
• W1963570357 countsByYear W19635703572023 @default.
• W1963570357 crossrefType "journal-article" @default.
• W1963570357 hasAuthorship W1963570357A5009338710 @default.
• W1963570357 hasAuthorship W1963570357A5014521829 @default.
• W1963570357 hasAuthorship W1963570357A5025952630 @default.
• W1963570357 hasAuthorship W1963570357A5034104691 @default.
• W1963570357 hasAuthorship W1963570357A5035593148 @default.
• W1963570357 hasAuthorship W1963570357A5075914998 @default.
• W1963570357 hasAuthorship W1963570357A5076791897 @default.
• W1963570357 hasAuthorship W1963570357A5078467458 @default.
• W1963570357 hasConcept C108215921 @default.
• W1963570357 hasConcept C121608353 @default.
• W1963570357 hasConcept C126322002 @default.
• W1963570357 hasConcept C142724271 @default.
• W1963570357 hasConcept C1491633281 @default.
• W1963570357 hasConcept C153911025 @default.
• W1963570357 hasConcept C181199279 @default.
• W1963570357 hasConcept C190062978 @default.
• W1963570357 hasConcept C2776256026 @default.
• W1963570357 hasConcept C2778325069 @default.
• W1963570357 hasConcept C2780259306 @default.
• W1963570357 hasConcept C2780508388 @default.
• W1963570357 hasConcept C28406088 @default.
• W1963570357 hasConcept C502942594 @default.
• W1963570357 hasConcept C526805850 @default.
• W1963570357 hasConcept C54355233 @default.
• W1963570357 hasConcept C55493867 @default.
• W1963570357 hasConcept C71924100 @default.
• W1963570357 hasConcept C79879829 @default.
• W1963570357 hasConcept C81885089 @default.
• W1963570357 hasConcept C86803240 @default.
• W1963570357 hasConcept C96232424 @default.
• W1963570357 hasConcept C98274493 @default.
• W1963570357 hasConceptScore W1963570357C108215921 @default.
• W1963570357 hasConceptScore W1963570357C121608353 @default.
• W1963570357 hasConceptScore W1963570357C126322002 @default.
• W1963570357 hasConceptScore W1963570357C142724271 @default.
• W1963570357 hasConceptScore W1963570357C1491633281 @default.
• W1963570357 hasConceptScore W1963570357C153911025 @default.
• W1963570357 hasConceptScore W1963570357C181199279 @default.
• W1963570357 hasConceptScore W1963570357C190062978 @default.
• W1963570357 hasConceptScore W1963570357C2776256026 @default.

• next