FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963574603> ?p ?o ?g. }

• W1963574603 endingPage "73" @default.
• W1963574603 startingPage "67" @default.
• W1963574603 abstract "The corpus luteum (CL) forms after ovulation and acts as a temporary endocrine gland that produces progesterone (P4), a hormone that is essential for implantation and maintenance of pregnancy in mammals. In pregnant women, human chorionic gonadotropin (hCG) secreted by the conceptus prevents luteolysis. hCG also increases the survival of cultured human luteinized granulosa cells (hLGCs). To clarify the maintenance mechanism of the human CL, we investigated the effects of hCG and P4 receptor antagonists, onapristone (OP) and RU486, on the viability of hLGCs. With the patients’ consent, hLGCs were isolated from follicular aspirates for in vitro fertilization. The cells were cultured with hCG (0.1, 1, 10, 100 IU/ml), OP (10, 25, 50, 100 μM), RU486 (100 μM), P4 (1, 10, 25, 50 μM) or some combination of the four for 24 h. Cell viability was significantly increased by hCG (100 IU/ml) and significantly decreased by OP (100 μM) compared with the control. Cells treated with hCG and OP together were significantly less viable than the control and OP-treated cells. The combined treatment also significantly increased CASP3 activity and cleaved CASP3 protein expression. Furthermore, P4 addition reversed the reduction in cell viability caused by the combination of hCG and OP treatment. The overall findings suggest that hCG cooperates with P4 to increase survival of hLGCs and to induce apoptosis when P4 action supported by hCG is attenuated in the human CL." @default.
• W1963574603 created "2016-06-24" @default.
• W1963574603 creator A5006191190 @default.
• W1963574603 creator A5048560115 @default.
• W1963574603 creator A5056106763 @default.
• W1963574603 creator A5061291083 @default.
• W1963574603 creator A5072465751 @default.
• W1963574603 date "2015-01-01" @default.
• W1963574603 modified "2023-10-02" @default.
• W1963574603 title "Potential role of hCG in apoptosis of human luteinized granulosa cells" @default.
• W1963574603 cites W1556029557 @default.
• W1963574603 cites W1964942687 @default.
• W1963574603 cites W1970676081 @default.
• W1963574603 cites W1973331693 @default.
• W1963574603 cites W1976881265 @default.
• W1963574603 cites W1992430845 @default.
• W1963574603 cites W1992784217 @default.
• W1963574603 cites W1993414868 @default.
• W1963574603 cites W2002357201 @default.
• W1963574603 cites W2007795861 @default.
• W1963574603 cites W2007951223 @default.
• W1963574603 cites W2010917680 @default.
• W1963574603 cites W2021525677 @default.
• W1963574603 cites W2024440558 @default.
• W1963574603 cites W2039733922 @default.
• W1963574603 cites W2052613188 @default.
• W1963574603 cites W2058401583 @default.
• W1963574603 cites W2060528857 @default.
• W1963574603 cites W2061107150 @default.
• W1963574603 cites W2082531353 @default.
• W1963574603 cites W2084808560 @default.
• W1963574603 cites W2090621088 @default.
• W1963574603 cites W2092011175 @default.
• W1963574603 cites W2096791929 @default.
• W1963574603 cites W2108367160 @default.
• W1963574603 cites W2116841131 @default.
• W1963574603 cites W2117939106 @default.
• W1963574603 cites W2121401422 @default.
• W1963574603 cites W2124784677 @default.
• W1963574603 cites W2132341450 @default.
• W1963574603 cites W2137361939 @default.
• W1963574603 cites W2140849886 @default.
• W1963574603 cites W2146116800 @default.
• W1963574603 cites W2151318628 @default.
• W1963574603 cites W2156282543 @default.
• W1963574603 cites W2418597684 @default.
• W1963574603 cites W4235894309 @default.
• W1963574603 cites W4241639231 @default.
• W1963574603 cites W4247803225 @default.
• W1963574603 cites W4255948227 @default.
• W1963574603 doi "https://doi.org/10.1262/jrd.2014-115" @default.
• W1963574603 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4354233" @default.
• W1963574603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25451535" @default.
• W1963574603 hasPublicationYear "2015" @default.
• W1963574603 type Work @default.
• W1963574603 sameAs 1963574603 @default.
• W1963574603 citedByCount "8" @default.
• W1963574603 countsByYear W19635746032016 @default.
• W1963574603 countsByYear W19635746032017 @default.
• W1963574603 countsByYear W19635746032018 @default.
• W1963574603 countsByYear W19635746032019 @default.
• W1963574603 countsByYear W19635746032020 @default.
• W1963574603 countsByYear W19635746032021 @default.
• W1963574603 countsByYear W19635746032023 @default.
• W1963574603 crossrefType "journal-article" @default.
• W1963574603 hasAuthorship W1963574603A5006191190 @default.
• W1963574603 hasAuthorship W1963574603A5048560115 @default.
• W1963574603 hasAuthorship W1963574603A5056106763 @default.
• W1963574603 hasAuthorship W1963574603A5061291083 @default.
• W1963574603 hasAuthorship W1963574603A5072465751 @default.
• W1963574603 hasBestOaLocation W19635746031 @default.
• W1963574603 hasConcept C126322002 @default.
• W1963574603 hasConcept C134018914 @default.
• W1963574603 hasConcept C16685009 @default.
• W1963574603 hasConcept C185592680 @default.
• W1963574603 hasConcept C187785154 @default.
• W1963574603 hasConcept C190283241 @default.
• W1963574603 hasConcept C2775948956 @default.
• W1963574603 hasConcept C2776608385 @default.
• W1963574603 hasConcept C2777330693 @default.
• W1963574603 hasConcept C2777702977 @default.
• W1963574603 hasConcept C2778826759 @default.
• W1963574603 hasConcept C2779234561 @default.
• W1963574603 hasConcept C54355233 @default.
• W1963574603 hasConcept C55493867 @default.
• W1963574603 hasConcept C71315377 @default.
• W1963574603 hasConcept C71924100 @default.
• W1963574603 hasConcept C86803240 @default.
• W1963574603 hasConceptScore W1963574603C126322002 @default.
• W1963574603 hasConceptScore W1963574603C134018914 @default.
• W1963574603 hasConceptScore W1963574603C16685009 @default.
• W1963574603 hasConceptScore W1963574603C185592680 @default.
• W1963574603 hasConceptScore W1963574603C187785154 @default.
• W1963574603 hasConceptScore W1963574603C190283241 @default.
• W1963574603 hasConceptScore W1963574603C2775948956 @default.
• W1963574603 hasConceptScore W1963574603C2776608385 @default.
• W1963574603 hasConceptScore W1963574603C2777330693 @default.
• W1963574603 hasConceptScore W1963574603C2777702977 @default.

• next