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• W1963575320 endingPage "S436" @default.
• W1963575320 startingPage "S429" @default.
• W1963575320 abstract "Background: IL-5 is fundamentally involved in eosinophilic inflammation. Control of IL-5 production may be effective for the management of allergic diseases. Objective: We aimed to find the transcriptional mechanisms that regulate the IL-5 gene to selectively control IL-5 synthesis. Methods: Allergen-specific T-cell clones and T-cell hybridomas were established from the peripheral blood lymphocytes of patients with asthma, and the transcriptional regulation of the IL-5 gene was investigated with transient transfection and electrophoretic mobility shift analysis. Results: A human IL-5 promoter/enhancer–luciferase gene construct, pIL-5(-511)Luc, was transcribed on activation of IL-5–producing T-cell clones, but not IL-5–nonproducing clones. pIL-5(–511)Luc was transcribed by T-cell hybridomas derived from fusion between IL-5–producing T-cell clones and an IL-5 gene–nonexpressing T-cell line, but not by hybridomas derived from IL-5–nonproducing T-cell clones. IL-5 synthesis was not only induced by T-cell receptor stimulation but also by IL-2 receptor stimulation. Binding of NF-AT, NF-κB, and AP-1 was induced by T-cell receptor (TcR) stimulation, although there was no significant upregulation of binding by IL-2 stimulation. Conclusion: IL-5 synthesis by human helper T cells is regulated at the transcriptional level. A unique transcriptional mechanism distinct from those regulating the IL-2 or IL-4 genes seems to control the IL-5 gene. Selective regulation of IL-5 gene transcription may be useful for treating eosinophlic inflammation. (J Allergy Clin Immunol 1999;103:S429-36.)" @default.
• W1963575320 created "2016-06-24" @default.
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• W1963575320 date "1999-05-01" @default.
• W1963575320 modified "2023-10-14" @default.
• W1963575320 title "Transcriptional control of the IL-5 gene by human helper T cells: IL-5 synthesis is regulated independently from IL-2 or IL-4 synthesis" @default.
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• W1963575320 doi "https://doi.org/10.1016/s0091-6749(99)70158-2" @default.
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