Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963577160> ?p ?o ?g. }
- W1963577160 endingPage "42" @default.
- W1963577160 startingPage "35" @default.
- W1963577160 abstract "The pathogenic mechanisms that underlie Parkinson's disease remain unknown. Here, we review evidence from both sporadic and genetic forms of Parkinson's disease that implicate both mitochondria and oxidative stress as central players in disease pathogenesis. A systemic deficiency in complex I of the mitochondrial electron transport chain is evident in many patients with the disease. Oxidative stress caused by reactive metabolites of dopamine and alterations in the levels of iron and glutathione in the substantia nigra accompany this mitochondrial dysfunction. Recent evidence from studies on the genetic forms of parkinsonism with particular stress on DJ-1, parkin, and PINK-1 also suggest the involvement of mitochondria and oxidative stress." @default.
- W1963577160 created "2016-06-24" @default.
- W1963577160 creator A5036045566 @default.
- W1963577160 creator A5089421070 @default.
- W1963577160 date "2013-03-01" @default.
- W1963577160 modified "2023-09-29" @default.
- W1963577160 title "Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism" @default.
- W1963577160 cites W1483212110 @default.
- W1963577160 cites W1504584187 @default.
- W1963577160 cites W1521854746 @default.
- W1963577160 cites W1527671059 @default.
- W1963577160 cites W1561072761 @default.
- W1963577160 cites W1588570886 @default.
- W1963577160 cites W1759946603 @default.
- W1963577160 cites W1799692929 @default.
- W1963577160 cites W1877873625 @default.
- W1963577160 cites W1954514489 @default.
- W1963577160 cites W1964642241 @default.
- W1963577160 cites W1967127565 @default.
- W1963577160 cites W1967253002 @default.
- W1963577160 cites W1969800514 @default.
- W1963577160 cites W1976393002 @default.
- W1963577160 cites W1977817124 @default.
- W1963577160 cites W1977990240 @default.
- W1963577160 cites W1978163054 @default.
- W1963577160 cites W1979645469 @default.
- W1963577160 cites W1979696767 @default.
- W1963577160 cites W1979855532 @default.
- W1963577160 cites W1984940419 @default.
- W1963577160 cites W1985416646 @default.
- W1963577160 cites W1985613988 @default.
- W1963577160 cites W1985842394 @default.
- W1963577160 cites W1986383547 @default.
- W1963577160 cites W1987112001 @default.
- W1963577160 cites W1990162995 @default.
- W1963577160 cites W1991511436 @default.
- W1963577160 cites W1993479669 @default.
- W1963577160 cites W1993747379 @default.
- W1963577160 cites W1994367478 @default.
- W1963577160 cites W1995706959 @default.
- W1963577160 cites W2001110041 @default.
- W1963577160 cites W2001531966 @default.
- W1963577160 cites W2003867505 @default.
- W1963577160 cites W2004437670 @default.
- W1963577160 cites W2006421452 @default.
- W1963577160 cites W2006622455 @default.
- W1963577160 cites W2007997420 @default.
- W1963577160 cites W2011116207 @default.
- W1963577160 cites W2012609836 @default.
- W1963577160 cites W2012770364 @default.
- W1963577160 cites W2013460209 @default.
- W1963577160 cites W2015116743 @default.
- W1963577160 cites W2016344599 @default.
- W1963577160 cites W2016763882 @default.
- W1963577160 cites W2017407647 @default.
- W1963577160 cites W2017621114 @default.
- W1963577160 cites W2018080238 @default.
- W1963577160 cites W2021815999 @default.
- W1963577160 cites W2022164794 @default.
- W1963577160 cites W2023211111 @default.
- W1963577160 cites W2023572125 @default.
- W1963577160 cites W2025872915 @default.
- W1963577160 cites W2027822127 @default.
- W1963577160 cites W2029503022 @default.
- W1963577160 cites W2030386915 @default.
- W1963577160 cites W2033832481 @default.
- W1963577160 cites W2034087770 @default.
- W1963577160 cites W2035223100 @default.
- W1963577160 cites W2035731751 @default.
- W1963577160 cites W2036284918 @default.
- W1963577160 cites W2038829928 @default.
- W1963577160 cites W2041819417 @default.
- W1963577160 cites W2041831342 @default.
- W1963577160 cites W2042312044 @default.
- W1963577160 cites W2043817490 @default.
- W1963577160 cites W2044388847 @default.
- W1963577160 cites W2044897807 @default.
- W1963577160 cites W2050849483 @default.
- W1963577160 cites W2054602118 @default.
- W1963577160 cites W2055124287 @default.
- W1963577160 cites W2055464888 @default.
- W1963577160 cites W2055493228 @default.
- W1963577160 cites W2057695252 @default.
- W1963577160 cites W2060061148 @default.
- W1963577160 cites W2062920562 @default.
- W1963577160 cites W2063089997 @default.
- W1963577160 cites W2065498957 @default.
- W1963577160 cites W2066842081 @default.
- W1963577160 cites W2067851857 @default.
- W1963577160 cites W2068521882 @default.
- W1963577160 cites W2071406809 @default.
- W1963577160 cites W2072190564 @default.
- W1963577160 cites W2073449985 @default.
- W1963577160 cites W2074128319 @default.
- W1963577160 cites W2074397899 @default.
- W1963577160 cites W2074833985 @default.
- W1963577160 cites W2076999235 @default.
- W1963577160 cites W2077567337 @default.