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- W1963578979 abstract "Background: The most virulent strain isH. influenzaeType b (Hib) responsible for 95% of bloodstream and meningeal Haemophilus infections in children. Hib also constitutes a major portion of nasopharyngeal commensal flora in otherwise healthy individuals. This study was undertaken to analyze if there exist any significant genetic differences between invasive and commensalH. influenzaeisolates. Methods: Isolates causing invasive disease were cultured from sterile body fluid. Commensal isolates were obtained from the nasopharynx of healthy schoolgoing children aged 5-14 years. Isolates with type b serotype from both invasive and commensal isolates were detected through capB polymerase chain reaction and slide agglutination serotyping. In total 15 invasive and 13 commensal isolates were characterized through multi locus sequence typing. Results: Serotyping revealed that all 15 invasive isolates in this study were of Type b. Seven out of 13 commensal isolates were of serotype b and 6/13 were non-Type b. MLST results showed presence of two sequence types (STs) previously described and five new STs among the Indian invasive H. influenzaeisolates tested. Amongst the 13 nasopharyngeal isolates tested through MLST, nine distinct STs were discovered each of which were novel. Conclusion: In our study of MLST involving Hib of invasive and commensal origin, it was observed that invasive Hib did not demonstrate much variation in their genome. In contrast, genetic diversity among commensal Hib was much more common implying existence of two distinct evolutionary lineages among invasive and commensal Hib." @default.
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- W1963578979 date "2012-06-01" @default.
- W1963578979 modified "2023-09-28" @default.
- W1963578979 title "Multi locus sequence type comparison of invasive and commensal Haemophilus influenzae isolates from Delhi" @default.
- W1963578979 doi "https://doi.org/10.1016/j.ijid.2012.05.857" @default.
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