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- W1963580947 abstract "In many synapses, depletion and recruitment of releasable synaptic vesicles contribute to use-dependent synaptic depression and recovery. Recently it has been shown that high-frequency presynaptic stimulation enhances recovery from depression, which may be mediated by Ca2+. We addressed this issue by measuring quantal release rates at the calyx of Held synapse and found that transmission is mediated by a heterogeneous population of vesicles, with one subset releasing rapidly and recovering slowly and another one releasing reluctantly and recovering rapidly. Ca2+ promotes refilling of the rapidly releasing synaptic vesicle pool and calmodulin inhibitors block this effect. We propose that calmodulin-dependent refilling supports recovery from synaptic depression during high-frequency trains in concert with rapid recovery of the slowly releasing vesicles." @default.
- W1963580947 created "2016-06-24" @default.
- W1963580947 creator A5010904789 @default.
- W1963580947 creator A5027089376 @default.
- W1963580947 date "2001-12-01" @default.
- W1963580947 modified "2023-10-11" @default.
- W1963580947 title "Calmodulin Mediates Rapid Recruitment of Fast-Releasing Synaptic Vesicles at a Calyx-Type Synapse" @default.
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- W1963580947 doi "https://doi.org/10.1016/s0896-6273(01)00543-8" @default.
- W1963580947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11754842" @default.
- W1963580947 hasPublicationYear "2001" @default.
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