FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963587614> ?p ?o ?g. }

• W1963587614 endingPage "424" @default.
• W1963587614 startingPage "417" @default.
• W1963587614 abstract "Familial hypercholesterolemia (FH) is a genetic disorder that leads to premature heart disease or stroke if untreated. Statins are effective for individuals with FH but less than 20% of actual cases are diagnosed in the US and many people are not adherent to treatment. Using new knowledge regarding mutations responsible for FH, some European countries have developed genetic FH screening strategies, many of which have been shown to be cost-effective. This study evaluates the cost-effectiveness of genetic screening and lipid-based screening with statin adherence measures compared to lipid-based screening alone in the US.A decision tree was used to estimate disease detection with the three screening strategies, while a Markov model was used to model disease progression until death, quality-adjusted life years (QALYs) and costs from a US societal perspective.The results showed that Genetic Screening cost $15,594 for 18.29 QALYs per person and Lipid Screening with adherence measures cost $16,385 for 18.77 QALYs compared with $10,396 for 18.28 QALYs for Lipid Screening alone. The incremental cost-effectiveness ratio (ICER) of Genetic Screening versus Lipid Screening was $519,813/QALY and that of Lipid Screening with adherence measures versus Lipid Screening alone was $12,223/QALY. At a US willingness-to-pay threshold of $150,000/QALY Genetic Screening is not cost-effective compared with Lipid Screening. Sensitivity analyses showed that results were robust to reasonable variations in model parameters.Although genetic screening is currently not a cost-effective option in the US, health outcomes for FH individuals could benefit from adherence measures encouraging statin use." @default.
• W1963587614 created "2016-06-24" @default.
• W1963587614 creator A5054832207 @default.
• W1963587614 creator A5080378534 @default.
• W1963587614 date "2015-02-01" @default.
• W1963587614 modified "2023-09-26" @default.
• W1963587614 title "Cost-effectiveness analysis of alternative screening and treatment strategies for heterozygous familial hypercholesterolemia in the United States" @default.
• W1963587614 cites W1485562534 @default.
• W1963587614 cites W1509872532 @default.
• W1963587614 cites W1537598136 @default.
• W1963587614 cites W1799873623 @default.
• W1963587614 cites W1863726591 @default.
• W1963587614 cites W1973229741 @default.
• W1963587614 cites W1979871017 @default.
• W1963587614 cites W1991890714 @default.
• W1963587614 cites W1994222210 @default.
• W1963587614 cites W2000182266 @default.
• W1963587614 cites W2006050950 @default.
• W1963587614 cites W2010518325 @default.
• W1963587614 cites W2010902794 @default.
• W1963587614 cites W2013841756 @default.
• W1963587614 cites W2021617671 @default.
• W1963587614 cites W2027757325 @default.
• W1963587614 cites W2040170118 @default.
• W1963587614 cites W2044264099 @default.
• W1963587614 cites W2050856345 @default.
• W1963587614 cites W2050977476 @default.
• W1963587614 cites W2056748059 @default.
• W1963587614 cites W2057674977 @default.
• W1963587614 cites W2058647728 @default.
• W1963587614 cites W2063202912 @default.
• W1963587614 cites W2066457780 @default.
• W1963587614 cites W2075536943 @default.
• W1963587614 cites W2084576139 @default.
• W1963587614 cites W2088912407 @default.
• W1963587614 cites W2108708766 @default.
• W1963587614 cites W2113890084 @default.
• W1963587614 cites W2114115725 @default.
• W1963587614 cites W2121136447 @default.
• W1963587614 cites W2123415255 @default.
• W1963587614 cites W2127448855 @default.
• W1963587614 cites W2130483595 @default.
• W1963587614 cites W2132419106 @default.
• W1963587614 cites W2143799371 @default.
• W1963587614 cites W2146846821 @default.
• W1963587614 cites W2148092884 @default.
• W1963587614 cites W2154704322 @default.
• W1963587614 cites W2159181531 @default.
• W1963587614 cites W2160809506 @default.
• W1963587614 cites W4230870013 @default.
• W1963587614 cites W4292022394 @default.
• W1963587614 cites W4302087466 @default.
• W1963587614 doi "https://doi.org/10.1016/j.ijcard.2014.12.070" @default.
• W1963587614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25569270" @default.
• W1963587614 hasPublicationYear "2015" @default.
• W1963587614 type Work @default.
• W1963587614 sameAs 1963587614 @default.
• W1963587614 citedByCount "30" @default.
• W1963587614 countsByYear W19635876142015 @default.
• W1963587614 countsByYear W19635876142016 @default.
• W1963587614 countsByYear W19635876142017 @default.
• W1963587614 countsByYear W19635876142018 @default.
• W1963587614 countsByYear W19635876142019 @default.
• W1963587614 countsByYear W19635876142020 @default.
• W1963587614 countsByYear W19635876142021 @default.
• W1963587614 countsByYear W19635876142022 @default.
• W1963587614 countsByYear W19635876142023 @default.
• W1963587614 crossrefType "journal-article" @default.
• W1963587614 hasAuthorship W1963587614A5054832207 @default.
• W1963587614 hasAuthorship W1963587614A5080378534 @default.
• W1963587614 hasConcept C112930515 @default.
• W1963587614 hasConcept C126322002 @default.
• W1963587614 hasConcept C177713679 @default.
• W1963587614 hasConcept C187212893 @default.
• W1963587614 hasConcept C2776839432 @default.
• W1963587614 hasConcept C2778163477 @default.
• W1963587614 hasConcept C2779120738 @default.
• W1963587614 hasConcept C2779134260 @default.
• W1963587614 hasConcept C2780673598 @default.
• W1963587614 hasConcept C3019080777 @default.
• W1963587614 hasConcept C515549039 @default.
• W1963587614 hasConcept C64332521 @default.
• W1963587614 hasConcept C71924100 @default.
• W1963587614 hasConceptScore W1963587614C112930515 @default.
• W1963587614 hasConceptScore W1963587614C126322002 @default.
• W1963587614 hasConceptScore W1963587614C177713679 @default.
• W1963587614 hasConceptScore W1963587614C187212893 @default.
• W1963587614 hasConceptScore W1963587614C2776839432 @default.
• W1963587614 hasConceptScore W1963587614C2778163477 @default.
• W1963587614 hasConceptScore W1963587614C2779120738 @default.
• W1963587614 hasConceptScore W1963587614C2779134260 @default.
• W1963587614 hasConceptScore W1963587614C2780673598 @default.
• W1963587614 hasConceptScore W1963587614C3019080777 @default.
• W1963587614 hasConceptScore W1963587614C515549039 @default.
• W1963587614 hasConceptScore W1963587614C64332521 @default.
• W1963587614 hasConceptScore W1963587614C71924100 @default.
• W1963587614 hasLocation W19635876141 @default.
• W1963587614 hasLocation W19635876142 @default.

• next