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• W1963588307 abstract "<h3>Objective</h3> MicroRNA-205 (miRNA-205) was revealed as an attractive prognostic tumour biomarker in recent studies. However, the results of different studies have been inconsistent. We conducted a meta-analysis to elucidate the precise predictive value of miRNA-205 in various human malignant neoplasms. <h3>Design</h3> Meta-analysis. <h3>Data sources</h3> Qualified studies were identified up to 5 June 2014 by performing online searches in PubMed, EMBASE and Web of Science, and additional quality evaluations. <h3>Participants</h3> Seventeen eligible studies with 4827 patients were ultimately enrolled in this meta-analysis. <h3>Outcome measures</h3> The heterogeneity between studies was assessed using I² statistics. Pooled HRs with 95% CIs for patient survival and disease recurrence were calculated to investigate the correlation between miRNA-205 expression and cancer prognosis. <h3>Results</h3> Our results indicate that elevated miRNA-205 was significantly associated with enhanced overall survival in the breast cancer subgroup (HR=0.78, 95% CI 0.67 to 0.91) and superior disease-free survival/recurrence-free survival in the adenocarcinoma subgroup (HR=0.68, 95% CI 0.49 to 0.94). <h3>Conclusions</h3> miRNA-205 is a promising biomarker for predicting the recurrence and progression of patients with adenocarcinomas or breast cancer. Owing to its complex roles, further relevant studies are warranted." @default.
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• W1963588307 date "2015-01-22" @default.
• W1963588307 modified "2023-09-26" @default.
• W1963588307 title "Prognostic role of microRNA-205 in multiple human malignant neoplasms: a meta-analysis of 17 studies" @default.
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• W1963588307 doi "https://doi.org/10.1136/bmjopen-2014-006244" @default.
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