FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963600744> ?p ?o ?g. }

• W1963600744 endingPage "795" @default.
• W1963600744 startingPage "791" @default.
• W1963600744 abstract "Esophageal cancer (EC) in the Indian population presents in advanced stages with poor prognosis and warrants the identification of a non-invasive marker for early detection and better prognostic assessment. We have previously reported high prevalence of p53 protein accumulation in esophageal squamous-cell carcinomas (ESCCs). The present study was designed to determine (i) if esophageal cancer patients elicit a humoral immune response to intra-tumoral p53 protein accumulation and (ii) their relationship with p53 gene mutations. The goal was to compare the cellular events, p53 protein accumulation and gene mutations with the presence of serum anti-p53 antibodies (p53-Abs) and to assess the utility of serological p53-Ab analysis as a surrogate marker for p53 alterations in esophageal cancer. A high prevalence of circulating p53-Abs was observed in 36 of 60 (60%) ESCC patients. In a subset of 44 ESCCs, exons 5-9 of the p53 gene were examined for mutations by PCR and direct sequencing of PCR products. Mutational data have been correlated with p53-Abs and p53 protein accumulation in ESCCs. Circulating p53-Abs in ESCC patients were significantly associated with intra-tumoral p53 protein accumulation (p=0.0005). A strong correlation observed between humoral immune response against p53 protein, missense gene mutations and protein accumulation warrants the application of serological p53-Abs as a non-invasive surrogate marker in screening high-risk populations for early detection of malignancy." @default.
• W1963600744 created "2016-06-24" @default.
• W1963600744 creator A5035258801 @default.
• W1963600744 creator A5044413474 @default.
• W1963600744 creator A5050945412 @default.
• W1963600744 creator A5054229964 @default.
• W1963600744 creator A5056782240 @default.
• W1963600744 date "2000-03-15" @default.
• W1963600744 modified "2023-09-25" @default.
• W1963600744 title "Circulating p53 antibodies, p53 gene mutational profile and product accumulation in esophageal squamous-cell carcinoma in India" @default.
• W1963600744 cites W1483898176 @default.
• W1963600744 cites W1993935967 @default.
• W1963600744 cites W2033564584 @default.
• W1963600744 cites W2035769098 @default.
• W1963600744 cites W2062414686 @default.
• W1963600744 cites W2068622871 @default.
• W1963600744 cites W2069709114 @default.
• W1963600744 cites W2105808730 @default.
• W1963600744 cites W2125262267 @default.
• W1963600744 cites W2135071278 @default.
• W1963600744 cites W2149636481 @default.
• W1963600744 doi "https://doi.org/10.1002/(sici)1097-0215(20000315)85:6<791::aid-ijc9>3.0.co;2-k" @default.
• W1963600744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10709097" @default.
• W1963600744 hasPublicationYear "2000" @default.
• W1963600744 type Work @default.
• W1963600744 sameAs 1963600744 @default.
• W1963600744 citedByCount "54" @default.
• W1963600744 countsByYear W19636007442012 @default.
• W1963600744 countsByYear W19636007442013 @default.
• W1963600744 countsByYear W19636007442014 @default.
• W1963600744 countsByYear W19636007442015 @default.
• W1963600744 countsByYear W19636007442016 @default.
• W1963600744 countsByYear W19636007442017 @default.
• W1963600744 countsByYear W19636007442018 @default.
• W1963600744 countsByYear W19636007442019 @default.
• W1963600744 countsByYear W19636007442020 @default.
• W1963600744 countsByYear W19636007442021 @default.
• W1963600744 countsByYear W19636007442022 @default.
• W1963600744 crossrefType "journal-article" @default.
• W1963600744 hasAuthorship W1963600744A5035258801 @default.
• W1963600744 hasAuthorship W1963600744A5044413474 @default.
• W1963600744 hasAuthorship W1963600744A5050945412 @default.
• W1963600744 hasAuthorship W1963600744A5054229964 @default.
• W1963600744 hasAuthorship W1963600744A5056782240 @default.
• W1963600744 hasBestOaLocation W19636007441 @default.
• W1963600744 hasConcept C104317684 @default.
• W1963600744 hasConcept C121608353 @default.
• W1963600744 hasConcept C150194340 @default.
• W1963600744 hasConcept C159654299 @default.
• W1963600744 hasConcept C195286587 @default.
• W1963600744 hasConcept C203014093 @default.
• W1963600744 hasConcept C2777546739 @default.
• W1963600744 hasConcept C2779399171 @default.
• W1963600744 hasConcept C2779742542 @default.
• W1963600744 hasConcept C2908647359 @default.
• W1963600744 hasConcept C2994225774 @default.
• W1963600744 hasConcept C36823959 @default.
• W1963600744 hasConcept C45189115 @default.
• W1963600744 hasConcept C501734568 @default.
• W1963600744 hasConcept C502942594 @default.
• W1963600744 hasConcept C54355233 @default.
• W1963600744 hasConcept C71924100 @default.
• W1963600744 hasConcept C86803240 @default.
• W1963600744 hasConcept C8891405 @default.
• W1963600744 hasConcept C99454951 @default.
• W1963600744 hasConceptScore W1963600744C104317684 @default.
• W1963600744 hasConceptScore W1963600744C121608353 @default.
• W1963600744 hasConceptScore W1963600744C150194340 @default.
• W1963600744 hasConceptScore W1963600744C159654299 @default.
• W1963600744 hasConceptScore W1963600744C195286587 @default.
• W1963600744 hasConceptScore W1963600744C203014093 @default.
• W1963600744 hasConceptScore W1963600744C2777546739 @default.
• W1963600744 hasConceptScore W1963600744C2779399171 @default.
• W1963600744 hasConceptScore W1963600744C2779742542 @default.
• W1963600744 hasConceptScore W1963600744C2908647359 @default.
• W1963600744 hasConceptScore W1963600744C2994225774 @default.
• W1963600744 hasConceptScore W1963600744C36823959 @default.
• W1963600744 hasConceptScore W1963600744C45189115 @default.
• W1963600744 hasConceptScore W1963600744C501734568 @default.
• W1963600744 hasConceptScore W1963600744C502942594 @default.
• W1963600744 hasConceptScore W1963600744C54355233 @default.
• W1963600744 hasConceptScore W1963600744C71924100 @default.
• W1963600744 hasConceptScore W1963600744C86803240 @default.
• W1963600744 hasConceptScore W1963600744C8891405 @default.
• W1963600744 hasConceptScore W1963600744C99454951 @default.
• W1963600744 hasIssue "6" @default.
• W1963600744 hasLocation W19636007441 @default.
• W1963600744 hasLocation W19636007442 @default.
• W1963600744 hasOpenAccess W1963600744 @default.
• W1963600744 hasPrimaryLocation W19636007441 @default.
• W1963600744 hasRelatedWork W1535498719 @default.
• W1963600744 hasRelatedWork W191183980 @default.
• W1963600744 hasRelatedWork W1921465616 @default.
• W1963600744 hasRelatedWork W2163125688 @default.
• W1963600744 hasRelatedWork W2351329238 @default.
• W1963600744 hasRelatedWork W2362329934 @default.
• W1963600744 hasRelatedWork W2363458739 @default.
• W1963600744 hasRelatedWork W2378192860 @default.

• next