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• W1963602013 abstract "Pregnant ICR mice were given a single ip injection of 5 mg ochratoxin A/kg on day 11 or 13 of pregnancy. Concentrations of ochratoxin A in the maternal serum and tissues reached maximum levels within 2 hr of the injection and then decreased rapidly. The half-life of the toxin in serum was 28.7 hr on day 11 and 23.6 hr on day 13. On the other hand, the concentrations of ochratoxin A in the embryos were very low 2 hr after injection and then gradually increased up to 48 and 30 hr after injection on day 11 and 13, respectively. Pharmacokinetically, the embryo was found to be a ‘deep’ compartment. In mice treated with ochratoxin A on day 10 of pregnancy, the incidence of pyknotic cells in the telencephalon of the embryos began to increase 12 hr after injection to a peak between 36 and 48 hr, coinciding with the time of peak concentration of the toxin in the embryo." @default.
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• W1963602013 date "1987-01-01" @default.
• W1963602013 modified "2023-09-27" @default.
• W1963602013 title "Placental transfer of ochratoxin A and its cytotoxic effect on the mouse embryonic brain" @default.
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• W1963602013 doi "https://doi.org/10.1016/0278-6915(87)90302-4" @default.
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