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- W1963602488 abstract "The role of catecholamines in mediating the acquisition of amygdala-kindled seizures was investigated in juvenile rats administered intracisternal injections of 6-hydroxydopamine (6-OHDA) on postnatal days 1 and 2. Amygdala kindling was initiated on day 28, using stimulations delivered each hour through two consecutive stage V seizures. The 6-OHDA treatment resulted in a 53% increase in the overall rate of kindling in juvenile rats. This acceleration was confined primarily to the early phases of kindling in that the 6-OHDA-treated rats skipped the early kindling stages, and the later stages of kindling were unaffected. These findings support evidence from adult rats that catecholamines play a role in initially limiting the spread of seizure activity during kindled seizure acquisition; however, when the seizures have begun to generalize, the ability of catecholaminergic systems to inhibit seizure spread diminishes." @default.
- W1963602488 created "2016-06-24" @default.
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- W1963602488 date "1985-12-01" @default.
- W1963602488 modified "2023-09-23" @default.
- W1963602488 title "Amygdala kindling in juvenile rats following neonatal administration of 6-hydroxydopamine" @default.
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- W1963602488 doi "https://doi.org/10.1016/0014-4886(85)90156-6" @default.
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