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- W1963608935 abstract "The identification of significant individual factors causing complex diseases is challenging in genome-wide association studies (GWAS) since each factor has only a modest effect on the disease development mechanism. In this study, we hypothesize that the biological pathways that are targeted by these individual factors show higher conservation within and across populations. To test this hypothesis, we searched for the disease related pathways on two intracranial aneurysm GWAS in European and Japanese case–control cohorts. Even though there were a few significantly conserved SNPs within and between populations, seven of the top ten affected pathways were found significant in both populations. The probability of random occurrence of such an event is 2.44E−36. We therefore claim that even though each individual has a unique combination of factors involved in the mechanism of disease development, most targeted pathways that need to be altered by these factors are, for the most part, the same. These pathways can serve as disease markers. Individuals, for example, can be scanned for factors affecting the genes in marker pathways. Hence, individual factors of disease development can be determined; and this knowledge can be exploited for drug development and personalized therapeutic applications. Here, we discuss the potential avenues of pathway markers in medicine and their translation to preventive and individualized health care." @default.
- W1963608935 created "2016-06-24" @default.
- W1963608935 creator A5039717404 @default.
- W1963608935 creator A5063633515 @default.
- W1963608935 date "2013-03-06" @default.
- W1963608935 modified "2023-09-24" @default.
- W1963608935 title "The Identification of Pathway Markers in Intracranial Aneurysm Using Genome-Wide Association Data from Two Different Populations" @default.
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- W1963608935 cites W1980996290 @default.
- W1963608935 cites W1984645480 @default.
- W1963608935 cites W1987601332 @default.
- W1963608935 cites W1987620105 @default.
- W1963608935 cites W1994803330 @default.
- W1963608935 cites W1998003466 @default.
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- W1963608935 cites W2006176357 @default.
- W1963608935 cites W2014092663 @default.
- W1963608935 cites W2014863183 @default.
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- W1963608935 doi "https://doi.org/10.1371/journal.pone.0057022" @default.
- W1963608935 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3590201" @default.
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