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- W1963634703 abstract "Mammary gland growth was induced experimentally by daily injection of 200 mg. of progesterone with 200 μg. of estradiol benzoate or by the feeding of 20 mg. of diethylstilbestrol daily for periods of 60, 120, and 180 days to 20 heifers and one steer. Lactation was then initiated by daily injections of 0.3 mg. of estradiol benzoate per 100 lb. body weight for 14 days. Treatment for 180 and 120 days apparently did not stimulate any greater mammary gland growth than 100 mg. of progesterone and 100 μg. of estradiol benzoate injected daily for 180 days, used in previous studies. The average maximum daily milk yields for the 16 animals on the lower level of hormones was 22.7 lb. per day, compared with the maximum daily milk yield of 23.8 and 21.2 lb. for the 14 animals treated for 180 and 120 days, respectively, with the higher level of estrogen and progesterone.The mean maximum daily milk yield for the six heifers injected for 60 days was 10.2 lb. The average maximum daily milk yield for the three lowest producers was 3.9 lb., compared with 21.4 lb. per day for the three highest producers of this group.Twenty milligrams of diethylstilbestrol administered orally proved equally as effective as 200 μg. of estradiol benzoate injected subcutaneously in synergizing with 200 mg. of progesterone injected daily to stimulate mammary gland development.When the lactation curve of the experimental heifers began to decline after reaching their maximum milk yield, either estradiol benzoate at the level used to initiate lactation or the feeding of diethylstilbestrol at levels of 30 and 40 mg/day/100 lb. body weight was administered for seven days. During the week of administration, milk yield declined slightly. This was followed by a variable increase in milk yield for several weeks, reaching peaks of lactation, in some cases, above the initial maximum production." @default.
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- W1963634703 date "2007-10-01" @default.
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- W1963634703 title "P.3.c.032 Was clozapine prescribing delayed?" @default.
- W1963634703 doi "https://doi.org/10.1016/s0924-977x(07)70669-7" @default.
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