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- W1963649218 abstract "Abstract Purpose Treatment for early breast cancer is multimodal with radiotherapy playing a fundamental role. This study investigated the relationship between the depth of lung incorporated in the tangential chest wall fields and self-reported respiratory symptoms. Method A randomised trial was conducted with 350 patients from one radiotherapy centre, randomised to one of two lung depth categories (0–2cm or 0–2.5cm). The primary outcome measure was the self-reported incidence of dry unproductive cough (DUC) post-treatment. Results On an intention to treat basis no difference in post-treatment symptoms for DUC could be identified between the two lung depth categories. A logistic regression analysis identified patient age, the use of nodal irradiation, and symptoms of DUC pre-treatment as significant in determining the risk of patients developing symptoms post-treatment. Conclusion These results confirm the importance of considering total volume of lung incorporated in the radiotherapy portals (identified by the relationship between reported symptoms and the use of nodal irradiation). The results of this study serve to further emphasise the need for evidence-based study into the radiotherapy policies employed in the UK." @default.
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- W1963649218 date "2005-02-01" @default.
- W1963649218 modified "2023-09-23" @default.
- W1963649218 title "Radiotherapy for breast carcinoma: an evaluation of the relationship between the central lung depth and respiratory symptoms" @default.
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- W1963649218 doi "https://doi.org/10.1016/j.radi.2004.08.004" @default.
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