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- W1963651418 abstract "Thirteen patients with metastatic colorectal adenocarcinoma underwent treatment with continuous ambulatory 5-fluo-rouracil (5-FU) infusion 300 mg/m2/day and intermittent bolus methotrexate (MTX) (200 mg/m2) with calcium leucovorin (LCV) 10 mg/m2 orally every 6 h × four to eight doses given 24 h after MTX. Although MTX administration was planned every 14 days, the average time between treatments exceeded 19 days (range 14–42) because of excessive toxicity. All patients experienced toxicity at some time in their treatment course, requiring interruption of 5-FU infusion in 12 of 13 patients. Significant toxicities included stomatitis (13 of 13 patients), hand-foot syndrome (8 of 13 patients), and diarrhea (3 of 13 patients). Toxicity did not appear to be minimized by attenuation of MTX and/or 5-FU dosage or by increasing the dose and/or duration of LCV. At this dosage schedule the addition of MTX/LCV to 5-FU infusion results in excessive and unacceptable toxicity and does not appear to improve treatment results." @default.
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- W1963651418 date "1987-06-01" @default.
- W1963651418 modified "2023-09-25" @default.
- W1963651418 title "Continuous 5-Fluorouracil Infusion and Pulse Methotrexate/Leucovorin for Colorectal Adenocarcinoma A Report of Excessive Toxicity" @default.
- W1963651418 doi "https://doi.org/10.1097/00000421-198706000-00008" @default.
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