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• W1963653441 abstract "Recent genome-wide association studies (GWASs) have renewed interest in genetic determinants of a wide range of complex traits and disorders, including stroke.This paper reviews the current knowledge of genes that contribute to rare monogenic forms of stroke as well as more common 'garden variety' forms, focusing on the results of GWASs. Potential clinical pharmacogenetic and diagnostic applications of this information are considered. Publications from 1990 to September 2010 were identified through a Medline search using terms 'human stroke' and 'genetics', 'monogenic', 'familial', 'mutation', 'genome-wide association study', 'polymorphism', or 'genotype'.The review synthesizes and collates the current understanding of genes that are involved across a range of stroke subphenotypes.The complexity of stroke will make translation of genetic findings into new diagnostic or therapeutic tools relatively more challenging than for some other conditions and tempers the authors' enthusiasm for the eventual clinical utility of this information." @default.
• W1963653441 created "2016-06-24" @default.
• W1963653441 creator A5003837086 @default.
• W1963653441 creator A5035358062 @default.
• W1963653441 creator A5047140394 @default.
• W1963653441 date "2010-12-22" @default.
• W1963653441 modified "2023-09-24" @default.
• W1963653441 title "Genetic risk factors for stroke in the genome-wide association era" @default.
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• W1963653441 doi "https://doi.org/10.1517/17530059.2011.540567" @default.
• W1963653441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23484478" @default.
• W1963653441 hasPublicationYear "2010" @default.
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