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• W1963657135 abstract "The cell adhesion molecule L1 is highly expressed on embryonic axons and may play a role in axonal outgrowth and fasciculation. Generally only low levels of L1 are found in adult spinal cord except for intense labeling in Lissauer's tract, in laminae I–II, and on dorsolateral funicular axons. In this study we determine the source of L1 immunoreactivity in the dorsal spinal cord, the presence of L1 expression on sprouting axons, and the effect of exercise on L1 expression. We determined the source of L1 immunoreactivity in the superficial dorsal horn by performing acute unilateral rhizotomies (T12–L4) in adult rats. This resulted in a marked decrease in L1 expression in Lissauer's tract and laminae I–II on the deafferented side. The peptidergic and nonpeptidergic small-diameter primary afferent markers, calcitonin gene-related peptide (CGRP) and the lectin IB4 respectively, closely correlated with L1 expression and also decreased dramatically after rhizotomy. Considering its developmental role, we asked whether L1 was expressed on sprouting axons following chronic rhizotomy. L1 and CGRP, but not IB4, were detected on sprouting axons. Lastly, we investigated the effect of exercise on L1 expression by giving animals with chronic rhizotomies free access to an exercise wheel. After extensive exercise, L1, CGRP, and IB4 expression levels were unchanged compared with those of sedentary chronic animals. Combined, these data demonstrate that the dorsal root ganglia is a major source of L1-positive axons in the superficial dorsal horn, that both L1 and CGRP identify sprouting axons following rhizotomy, and that exercise does not upregulate L1 expression. J. Comp. Neurol. 485:267–279, 2005. © 2005 Wiley-Liss, Inc." @default.
• W1963657135 created "2016-06-24" @default.
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• W1963657135 date "2005-05-16" @default.
• W1963657135 modified "2023-10-12" @default.
• W1963657135 title "L1 CAM expression in the superficial dorsal horn is derived from the dorsal root ganglion" @default.
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• W1963657135 doi "https://doi.org/10.1002/cne.20479" @default.
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