FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963657377> ?p ?o ?g. }

• W1963657377 endingPage "e15417" @default.
• W1963657377 startingPage "e15417" @default.
• W1963657377 abstract "Allostery of P-selectin lectin (Lec) domain followed by an epithelial growth factor (EGF)-like domain is essential for its biological functionality, but the underlying pathways have not been well understood. Here the molecular dynamics simulations were performed on the crystallized structures to visualize the dynamic conformational change for state 1 (S1) or state 2 (S2) Lec domain with respective bent (B) or extended (E) EGF orientation. Simulations illustrated that both S1 and S2 conformations were unable to switch from one to another directly. Instead, a novel S1' conformation was observed from S1 when crystallized B-S1 or reconstructed E-S1 structure was employed, which was superposed well with that of equilibrated S1 Lec domain alone. It was also indicated that the corresponding allosteric pathway from S1 to S1' conformation started with the separation between residues Q30 and K67 and terminated with the release of residue N87 from residue C109. These results provided an insight into understanding the structural transition and the structure-function relationship of P-selectin allostery." @default.
• W1963657377 created "2016-06-24" @default.
• W1963657377 creator A5053746291 @default.
• W1963657377 creator A5073236451 @default.
• W1963657377 creator A5086664284 @default.
• W1963657377 date "2010-12-08" @default.
• W1963657377 modified "2023-09-26" @default.
• W1963657377 title "Visualization of Allostery in P-Selectin Lectin Domain Using MD Simulations" @default.
• W1963657377 cites W1965690163 @default.
• W1963657377 cites W1973532630 @default.
• W1963657377 cites W1977602054 @default.
• W1963657377 cites W1981594687 @default.
• W1963657377 cites W1984845371 @default.
• W1963657377 cites W2008415358 @default.
• W1963657377 cites W2012275753 @default.
• W1963657377 cites W2025735516 @default.
• W1963657377 cites W2027408247 @default.
• W1963657377 cites W2029667189 @default.
• W1963657377 cites W2044162092 @default.
• W1963657377 cites W2051369945 @default.
• W1963657377 cites W2101030382 @default.
• W1963657377 cites W2104418223 @default.
• W1963657377 cites W2112998064 @default.
• W1963657377 cites W2126278579 @default.
• W1963657377 cites W2131535445 @default.
• W1963657377 cites W2140449516 @default.
• W1963657377 cites W2141411766 @default.
• W1963657377 cites W2148935856 @default.
• W1963657377 cites W2150981663 @default.
• W1963657377 cites W2153395732 @default.
• W1963657377 cites W2159304854 @default.
• W1963657377 cites W2160648230 @default.
• W1963657377 cites W2171954415 @default.
• W1963657377 cites W4246991801 @default.
• W1963657377 cites W77656453 @default.
• W1963657377 doi "https://doi.org/10.1371/journal.pone.0015417" @default.
• W1963657377 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2999562" @default.
• W1963657377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21170343" @default.
• W1963657377 hasPublicationYear "2010" @default.
• W1963657377 type Work @default.
• W1963657377 sameAs 1963657377 @default.
• W1963657377 citedByCount "12" @default.
• W1963657377 countsByYear W19636573772013 @default.
• W1963657377 countsByYear W19636573772014 @default.
• W1963657377 countsByYear W19636573772015 @default.
• W1963657377 countsByYear W19636573772017 @default.
• W1963657377 countsByYear W19636573772021 @default.
• W1963657377 countsByYear W19636573772023 @default.
• W1963657377 crossrefType "journal-article" @default.
• W1963657377 hasAuthorship W1963657377A5053746291 @default.
• W1963657377 hasAuthorship W1963657377A5073236451 @default.
• W1963657377 hasAuthorship W1963657377A5086664284 @default.
• W1963657377 hasBestOaLocation W19636573771 @default.
• W1963657377 hasConcept C12554922 @default.
• W1963657377 hasConcept C147597530 @default.
• W1963657377 hasConcept C166342909 @default.
• W1963657377 hasConcept C170493617 @default.
• W1963657377 hasConcept C185592680 @default.
• W1963657377 hasConcept C2780758401 @default.
• W1963657377 hasConcept C2781338088 @default.
• W1963657377 hasConcept C47701112 @default.
• W1963657377 hasConcept C55493867 @default.
• W1963657377 hasConcept C59593255 @default.
• W1963657377 hasConcept C8010536 @default.
• W1963657377 hasConcept C86803240 @default.
• W1963657377 hasConceptScore W1963657377C12554922 @default.
• W1963657377 hasConceptScore W1963657377C147597530 @default.
• W1963657377 hasConceptScore W1963657377C166342909 @default.
• W1963657377 hasConceptScore W1963657377C170493617 @default.
• W1963657377 hasConceptScore W1963657377C185592680 @default.
• W1963657377 hasConceptScore W1963657377C2780758401 @default.
• W1963657377 hasConceptScore W1963657377C2781338088 @default.
• W1963657377 hasConceptScore W1963657377C47701112 @default.
• W1963657377 hasConceptScore W1963657377C55493867 @default.
• W1963657377 hasConceptScore W1963657377C59593255 @default.
• W1963657377 hasConceptScore W1963657377C8010536 @default.
• W1963657377 hasConceptScore W1963657377C86803240 @default.
• W1963657377 hasIssue "12" @default.
• W1963657377 hasLocation W19636573771 @default.
• W1963657377 hasLocation W19636573772 @default.
• W1963657377 hasLocation W19636573773 @default.
• W1963657377 hasLocation W19636573774 @default.
• W1963657377 hasLocation W19636573775 @default.
• W1963657377 hasOpenAccess W1963657377 @default.
• W1963657377 hasPrimaryLocation W19636573771 @default.
• W1963657377 hasRelatedWork W1993910833 @default.
• W1963657377 hasRelatedWork W2012303202 @default.
• W1963657377 hasRelatedWork W2069491351 @default.
• W1963657377 hasRelatedWork W2117563536 @default.
• W1963657377 hasRelatedWork W2469342451 @default.
• W1963657377 hasRelatedWork W2950269921 @default.
• W1963657377 hasRelatedWork W3157523411 @default.
• W1963657377 hasRelatedWork W3194520185 @default.
• W1963657377 hasRelatedWork W4253425766 @default.
• W1963657377 hasRelatedWork W4379203175 @default.
• W1963657377 hasVolume "5" @default.
• W1963657377 isParatext "false" @default.
• W1963657377 isRetracted "false" @default.

• next