FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963660064> ?p ?o ?g. }

• W1963660064 endingPage "365" @default.
• W1963660064 startingPage "352" @default.
• W1963660064 abstract "We have previously demonstrated that the anti-inflammatory prostaglandin 15-deoxy-Δ 12,14-prostaglandin J2 (15dPGJ2) delays inflammation-induced preterm labour in the mouse and improves pup survival through the inhibition of nuclear factor-κB (NF-κB) by a mechanism yet to be elucidated. 15dPGJ2 is an agonist of the second prostaglandin D2 receptor, chemoattractant receptor homologous to the T helper 2 cell (CRTH2). In human T helper cells CRTH2 agonists induce the production of the anti-inflammatory interleukins IL-10 and IL-4. We hypothesized that CRTH2 is involved in the protective effect of 15dPGJ2 in inflammation-induced preterm labour in the murine model. We therefore studied the effects of a specific small molecule CRTH2 agonist on preterm labour and pup survival. An intrauterine injection of lipopolysaccharide (LPS) was administered to CD1 mice at embryonic day 16, ± CRTH2 agonist/vehicle controls. Mice were killed at 4.5 hr to assess fetal wellbeing and to harvest myometrium and pup brain for analysis of NF-κB, and T helper type 1/2 interleukins. To examine the effects of the CRTH2 agonist on LPS-induced preterm labour, mice were allowed to labour spontaneously. Direct effects of the CRTH2 agonist on uterine contractility were examined ex vivo on contracting myometrial strips. The CRTH2 agonist increased fetal survival from 20 to 100% in LPS-treated mice, and inhibited circular muscle contractility ex vivo. However, it augmented LPS-induced labour and significantly increased myometrial NF-κB, IL-1β, KC-GRO, interferon-γ and tumour necrosis factor-α. This suggests that the action of 15dPGJ2 is not via CRTH2 and therefore small molecule CRTH2 agonists are not likely to be beneficial for the prevention of inflammation-induced preterm labour." @default.
• W1963660064 created "2016-06-24" @default.
• W1963660064 creator A5000300560 @default.
• W1963660064 creator A5004235876 @default.
• W1963660064 creator A5009393702 @default.
• W1963660064 creator A5025297198 @default.
• W1963660064 creator A5051046329 @default.
• W1963660064 creator A5067317460 @default.
• W1963660064 creator A5071712270 @default.
• W1963660064 creator A5082086200 @default.
• W1963660064 date "2013-06-13" @default.
• W1963660064 modified "2023-09-26" @default.
• W1963660064 title "The CRTH2 agonist Pyl A prevents lipopolysaccharide-induced fetal death but induces preterm labour" @default.
• W1963660064 cites W1517598754 @default.
• W1963660064 cites W1779958125 @default.
• W1963660064 cites W1929902529 @default.
• W1963660064 cites W1970122977 @default.
• W1963660064 cites W1971595233 @default.
• W1963660064 cites W1973156391 @default.
• W1963660064 cites W1973470362 @default.
• W1963660064 cites W1976728837 @default.
• W1963660064 cites W1980907378 @default.
• W1963660064 cites W1982567306 @default.
• W1963660064 cites W1989750047 @default.
• W1963660064 cites W1996601338 @default.
• W1963660064 cites W1997042650 @default.
• W1963660064 cites W1999564321 @default.
• W1963660064 cites W1999564936 @default.
• W1963660064 cites W2004361843 @default.
• W1963660064 cites W2005298532 @default.
• W1963660064 cites W2010293066 @default.
• W1963660064 cites W2019291960 @default.
• W1963660064 cites W2020695556 @default.
• W1963660064 cites W2024120977 @default.
• W1963660064 cites W2026465899 @default.
• W1963660064 cites W2029473902 @default.
• W1963660064 cites W2030634089 @default.
• W1963660064 cites W2032875315 @default.
• W1963660064 cites W2034243134 @default.
• W1963660064 cites W2040424925 @default.
• W1963660064 cites W2040981816 @default.
• W1963660064 cites W2042738623 @default.
• W1963660064 cites W2043016107 @default.
• W1963660064 cites W2050019045 @default.
• W1963660064 cites W2050717908 @default.
• W1963660064 cites W2051868855 @default.
• W1963660064 cites W2051870934 @default.
• W1963660064 cites W2052090795 @default.
• W1963660064 cites W2053894571 @default.
• W1963660064 cites W2054142059 @default.
• W1963660064 cites W2066882388 @default.
• W1963660064 cites W2068484442 @default.
• W1963660064 cites W2073651858 @default.
• W1963660064 cites W2073939652 @default.
• W1963660064 cites W2085007769 @default.
• W1963660064 cites W2086508570 @default.
• W1963660064 cites W2093949929 @default.
• W1963660064 cites W2097096084 @default.
• W1963660064 cites W2100705331 @default.
• W1963660064 cites W2104712354 @default.
• W1963660064 cites W2112468046 @default.
• W1963660064 cites W2112623150 @default.
• W1963660064 cites W2118982376 @default.
• W1963660064 cites W2122044177 @default.
• W1963660064 cites W2122749412 @default.
• W1963660064 cites W2130032485 @default.
• W1963660064 cites W2133984874 @default.
• W1963660064 cites W2136224038 @default.
• W1963660064 cites W2137107070 @default.
• W1963660064 cites W2142233952 @default.
• W1963660064 cites W2145957843 @default.
• W1963660064 cites W2146451371 @default.
• W1963660064 cites W2150033965 @default.
• W1963660064 cites W2156353286 @default.
• W1963660064 cites W2156797817 @default.
• W1963660064 cites W2160634538 @default.
• W1963660064 cites W2161383771 @default.
• W1963660064 cites W2163870925 @default.
• W1963660064 cites W2165438365 @default.
• W1963660064 cites W2166893697 @default.
• W1963660064 cites W2199156859 @default.
• W1963660064 cites W4211135592 @default.
• W1963660064 cites W4244061402 @default.
• W1963660064 cites W4248441649 @default.
• W1963660064 cites W4313324525 @default.
• W1963660064 cites W95988660 @default.
• W1963660064 doi "https://doi.org/10.1111/imm.12085" @default.
• W1963660064 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3701182" @default.
• W1963660064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23374103" @default.
• W1963660064 hasPublicationYear "2013" @default.
• W1963660064 type Work @default.
• W1963660064 sameAs 1963660064 @default.
• W1963660064 citedByCount "3" @default.
• W1963660064 countsByYear W19636600642014 @default.
• W1963660064 countsByYear W19636600642015 @default.
• W1963660064 countsByYear W19636600642022 @default.
• W1963660064 crossrefType "journal-article" @default.
• W1963660064 hasAuthorship W1963660064A5000300560 @default.

• next