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• W1963662073 abstract "We have investigated the effect of staurosporine and other kinase inhibitors on the mRNA and protein levels of the P-glycoprotein (P-gp) in multidrug resistant (MDR) cells. Treatment of human MDR KB-V1 cells with staurosporine for 24 h caused up to a 50% decrease in the amount of P-gp mRNA and protein present. Co-treatment of KB-V1 cells with verapamil, a known reversal agent, plus staurosporine, H-9, or K252a resulted in an enhanced sensitization of cells to vinblastine than with verapamil alone. These findings support a role for protein kinases in the control of multidrug resistance through effects on P-gp levels." @default.
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• W1963662073 date "1993-01-01" @default.
• W1963662073 modified "2023-10-16" @default.
• W1963662073 title "Staurosporine reduces P-glycoprotein expression and modulates multidrug resistance" @default.
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• W1963662073 doi "https://doi.org/10.1016/0304-3835(93)90213-s" @default.
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