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• W1963662941 abstract "Exophilin8/MyRIP/Slac2-c is an effector protein of the small GTPase Rab27a and is specifically localized on retinal melanosomes and secretory granules. We investigated the role of exophilin8 in insulin granule trafficking. Exogenous expression of exophilin8 in pancreatic β cells or their cell line, MIN6, polarized (exophilin8-positive) insulin granules at the cell corners, where both cortical actin and the microtubule plus-end-binding protein, EB1, were present. Mutation analyses indicated that the ability of exophilin8 to act as a linker between Rab27a and myosin Va is essential for its granule-clustering activity. Moreover, exophilin8 and exophilin8-associated insulin granules were markedly stable and immobile. Total internal reflection fluorescence microscopy indicated that exophilin8 restricts the motion of insulin granules at a region deeper than that where another Rab27a effector, granuphilin, accumulates docked granules directly attached to the plasma membrane. However, the exophilin8-induced immobility of insulin granules was eliminated upon secretagogue stimulation and did not inhibit evoked exocytosis. Furthermore, exophilin8 depletion prevents insulin granules from being transported close to the plasma membrane and inhibits their fusion. These findings indicate that exophilin8 transiently traps insulin granules into the cortical actin network close to the microtubule plus-ends and supplies them for release during the stimulation." @default.
• W1963662941 created "2016-06-24" @default.
• W1963662941 creator A5043485685 @default.
• W1963662941 creator A5082138632 @default.
• W1963662941 creator A5089136154 @default.
• W1963662941 date "2011-05-15" @default.
• W1963662941 modified "2023-10-14" @default.
• W1963662941 title "Exophilin8 transiently clusters insulin granules at the actin-rich cell cortex prior to exocytosis" @default.
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• W1963662941 doi "https://doi.org/10.1091/mbc.e10-05-0404" @default.
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• W1963662941 hasPublicationYear "2011" @default.
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