FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963668480> ?p ?o ?g. }

• W1963668480 endingPage "1481" @default.
• W1963668480 startingPage "1475" @default.
• W1963668480 abstract "Intracellular pH (pHi) and developed pressure during hypercapnic acidosis were studied in the spontaneously hypertensive rat (SHR) heart and Wistar-Kyoto controls. Developed pressure was determined using a modified Langendorff isovolumic perfusion technique and 31P magnetic resonance spectroscopy was used to determine pHi. In response to acidosis, both developed pressure and pHi first decreased and then partially recovered. In the SHR group, pHi during the early periods of acidosis was significantly higher than in the control group while there was no significant difference in the steady-state pHi. The addition of 5-(N,N)-hexamethylene-amiloride (HMA), a specific inhibitor of Na+-H+ exchange, abolished these differences. Furthermore, HMA was found to inhibit recovery in pHi and developed pressure during acidosis in both groups. These results demonstrate that Na+-H+-exchange in the rat heart plays a major role in pHi regulation and contributes to functional recovery during acidosis. In addition, Na+-H+-exchange activity, as previously found in other tissues in hypertension, is increased in the SHR heart. Intracellular pH (pHi) and developed pressure during hypercapnic acidosis were studied in the spontaneously hypertensive rat (SHR) heart and Wistar-Kyoto controls. Developed pressure was determined using a modified Langendorff isovolumic perfusion technique and 31P magnetic resonance spectroscopy was used to determine pHi. In response to acidosis, both developed pressure and pHi first decreased and then partially recovered. In the SHR group, pHi during the early periods of acidosis was significantly higher than in the control group while there was no significant difference in the steady-state pHi. The addition of 5-(N,N)-hexamethylene-amiloride (HMA), a specific inhibitor of Na+-H+ exchange, abolished these differences. Furthermore, HMA was found to inhibit recovery in pHi and developed pressure during acidosis in both groups. These results demonstrate that Na+-H+-exchange in the rat heart plays a major role in pHi regulation and contributes to functional recovery during acidosis. In addition, Na+-H+-exchange activity, as previously found in other tissues in hypertension, is increased in the SHR heart." @default.
• W1963668480 created "2016-06-24" @default.
• W1963668480 creator A5004531420 @default.
• W1963668480 creator A5040554416 @default.
• W1963668480 date "1995-08-01" @default.
• W1963668480 modified "2023-10-14" @default.
• W1963668480 title "Altered Na+-H+-exchange activity in the spontaneously hypertensive perfused rat heart" @default.
• W1963668480 cites W1509551118 @default.
• W1963668480 cites W1578086030 @default.
• W1963668480 cites W1840325563 @default.
• W1963668480 cites W1947794470 @default.
• W1963668480 cites W1964025667 @default.
• W1963668480 cites W1966647373 @default.
• W1963668480 cites W1973968263 @default.
• W1963668480 cites W1977923285 @default.
• W1963668480 cites W1987051971 @default.
• W1963668480 cites W1989314580 @default.
• W1963668480 cites W1991875115 @default.
• W1963668480 cites W1992900591 @default.
• W1963668480 cites W2011063531 @default.
• W1963668480 cites W2018848106 @default.
• W1963668480 cites W2054548209 @default.
• W1963668480 cites W2055428781 @default.
• W1963668480 cites W2056109345 @default.
• W1963668480 cites W2057595921 @default.
• W1963668480 cites W2066872657 @default.
• W1963668480 cites W2073157483 @default.
• W1963668480 cites W2083819298 @default.
• W1963668480 cites W2086245657 @default.
• W1963668480 cites W2089611263 @default.
• W1963668480 cites W2089675043 @default.
• W1963668480 cites W2113950363 @default.
• W1963668480 cites W2117631539 @default.
• W1963668480 cites W2162795944 @default.
• W1963668480 cites W2163129250 @default.
• W1963668480 cites W2178581192 @default.
• W1963668480 cites W2183824164 @default.
• W1963668480 cites W2205329504 @default.
• W1963668480 cites W2237534382 @default.
• W1963668480 cites W2285672337 @default.
• W1963668480 cites W2286152392 @default.
• W1963668480 cites W2336903283 @default.
• W1963668480 cites W2339284332 @default.
• W1963668480 cites W2405243768 @default.
• W1963668480 cites W2408978288 @default.
• W1963668480 cites W2414450345 @default.
• W1963668480 cites W2415496155 @default.
• W1963668480 cites W2442246487 @default.
• W1963668480 cites W613972312 @default.
• W1963668480 doi "https://doi.org/10.1016/s0022-2828(95)90128-0" @default.
• W1963668480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8523411" @default.
• W1963668480 hasPublicationYear "1995" @default.
• W1963668480 type Work @default.
• W1963668480 sameAs 1963668480 @default.
• W1963668480 citedByCount "24" @default.
• W1963668480 countsByYear W19636684802012 @default.
• W1963668480 countsByYear W19636684802018 @default.
• W1963668480 countsByYear W19636684802020 @default.
• W1963668480 countsByYear W19636684802023 @default.
• W1963668480 crossrefType "journal-article" @default.
• W1963668480 hasAuthorship W1963668480A5004531420 @default.
• W1963668480 hasAuthorship W1963668480A5040554416 @default.
• W1963668480 hasConcept C114574056 @default.
• W1963668480 hasConcept C126322002 @default.
• W1963668480 hasConcept C134018914 @default.
• W1963668480 hasConcept C134897140 @default.
• W1963668480 hasConcept C146957229 @default.
• W1963668480 hasConcept C178790620 @default.
• W1963668480 hasConcept C185592680 @default.
• W1963668480 hasConcept C2778553927 @default.
• W1963668480 hasConcept C2779608910 @default.
• W1963668480 hasConcept C537181965 @default.
• W1963668480 hasConcept C55493867 @default.
• W1963668480 hasConcept C71924100 @default.
• W1963668480 hasConcept C79879829 @default.
• W1963668480 hasConceptScore W1963668480C114574056 @default.
• W1963668480 hasConceptScore W1963668480C126322002 @default.
• W1963668480 hasConceptScore W1963668480C134018914 @default.
• W1963668480 hasConceptScore W1963668480C134897140 @default.
• W1963668480 hasConceptScore W1963668480C146957229 @default.
• W1963668480 hasConceptScore W1963668480C178790620 @default.
• W1963668480 hasConceptScore W1963668480C185592680 @default.
• W1963668480 hasConceptScore W1963668480C2778553927 @default.
• W1963668480 hasConceptScore W1963668480C2779608910 @default.
• W1963668480 hasConceptScore W1963668480C537181965 @default.
• W1963668480 hasConceptScore W1963668480C55493867 @default.
• W1963668480 hasConceptScore W1963668480C71924100 @default.
• W1963668480 hasConceptScore W1963668480C79879829 @default.
• W1963668480 hasIssue "8" @default.
• W1963668480 hasLocation W19636684801 @default.
• W1963668480 hasLocation W19636684802 @default.
• W1963668480 hasOpenAccess W1963668480 @default.
• W1963668480 hasPrimaryLocation W19636684801 @default.
• W1963668480 hasRelatedWork W1614256109 @default.
• W1963668480 hasRelatedWork W1828876468 @default.
• W1963668480 hasRelatedWork W1986876542 @default.
• W1963668480 hasRelatedWork W2074798815 @default.
• W1963668480 hasRelatedWork W2106073562 @default.

• next