FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963669299> ?p ?o ?g. }

• W1963669299 endingPage "511" @default.
• W1963669299 startingPage "504" @default.
• W1963669299 abstract "All mutations known to cause familial Alzheimer's disease (AD) act by increasing the levels of soluble β-amyloid peptide (Aβ), especially the longer form, Aβ42. However, in vivo elevation of soluble Aβ in sporadic AD has so far not been shown. In the present study, we used enzyme-linked immunosorbent assays specific for Aβ42 and Aβ40 to investigate cerebrospinal fluid from sporadic AD at different stages of disease severity, to clarify the roles of Aβ42 and Aβ40 during disease progression. We also evaluated three other groups—one group of patients with mild cognitive impairment who were at risk of developing dementia, a cognitively intact, nondemented reference group diagnosed with depression, and a perfectly healthy control group. We found that Aβ42 is strongly elevated in early and mid stages of AD, and thereafter it declines with disease progression. On the contrary, Aβ40 levels were decreased in early and mid stages of AD. The group of cognitively impaired patients and the depression reference group had significantly higher levels of Aβ42 than the healthy control group, implying that Aβ42 is increased not only in AD, but in other central nervous system conditions as well. Our data also point out the importance of having thoroughly examined control material. The initial increase and subsequent decrease of Aβ42 adds a new biochemical tool to follow the progression of AD and might be important in the monitoring of therapeutics. Ann Neurol 1999;45:504–511" @default.
• W1963669299 created "2016-06-24" @default.
• W1963669299 creator A5013866441 @default.
• W1963669299 creator A5014352801 @default.
• W1963669299 creator A5018345023 @default.
• W1963669299 creator A5024091596 @default.
• W1963669299 creator A5027835558 @default.
• W1963669299 creator A5027957688 @default.
• W1963669299 creator A5034690488 @default.
• W1963669299 creator A5035250882 @default.
• W1963669299 creator A5046904851 @default.
• W1963669299 creator A5049494615 @default.
• W1963669299 creator A5055020473 @default.
• W1963669299 creator A5063105528 @default.
• W1963669299 creator A5064378943 @default.
• W1963669299 date "1999-04-01" @default.
• W1963669299 modified "2023-10-18" @default.
• W1963669299 title "Cerebrospinal fluid A?42 is increased early in sporadic Alzheimer's disease and declines with disease progression" @default.
• W1963669299 cites W1531123859 @default.
• W1963669299 cites W1605023308 @default.
• W1963669299 cites W1644143258 @default.
• W1963669299 cites W1847168837 @default.
• W1963669299 cites W1967684462 @default.
• W1963669299 cites W1978566291 @default.
• W1963669299 cites W1979773315 @default.
• W1963669299 cites W1981554609 @default.
• W1963669299 cites W1982341565 @default.
• W1963669299 cites W1985325561 @default.
• W1963669299 cites W1991413414 @default.
• W1963669299 cites W1995175521 @default.
• W1963669299 cites W2001834310 @default.
• W1963669299 cites W2004531476 @default.
• W1963669299 cites W2007633933 @default.
• W1963669299 cites W2010245335 @default.
• W1963669299 cites W2025290060 @default.
• W1963669299 cites W2027136096 @default.
• W1963669299 cites W2045471895 @default.
• W1963669299 cites W2049054180 @default.
• W1963669299 cites W2051261126 @default.
• W1963669299 cites W2054147868 @default.
• W1963669299 cites W2060579161 @default.
• W1963669299 cites W2070045579 @default.
• W1963669299 cites W2079438371 @default.
• W1963669299 cites W2081998222 @default.
• W1963669299 cites W2095745901 @default.
• W1963669299 cites W2101077392 @default.
• W1963669299 cites W2102032026 @default.
• W1963669299 cites W2111548061 @default.
• W1963669299 cites W2128963115 @default.
• W1963669299 cites W2134379460 @default.
• W1963669299 cites W2136680662 @default.
• W1963669299 cites W2143256002 @default.
• W1963669299 cites W2148750503 @default.
• W1963669299 cites W2156220037 @default.
• W1963669299 cites W2163652052 @default.
• W1963669299 doi "https://doi.org/10.1002/1531-8249(199904)45:4<504::aid-ana12>3.0.co;2-9" @default.
• W1963669299 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10211475" @default.
• W1963669299 hasPublicationYear "1999" @default.
• W1963669299 type Work @default.
• W1963669299 sameAs 1963669299 @default.
• W1963669299 citedByCount "203" @default.
• W1963669299 countsByYear W19636692992012 @default.
• W1963669299 countsByYear W19636692992013 @default.
• W1963669299 countsByYear W19636692992014 @default.
• W1963669299 countsByYear W19636692992015 @default.
• W1963669299 countsByYear W19636692992016 @default.
• W1963669299 countsByYear W19636692992017 @default.
• W1963669299 countsByYear W19636692992018 @default.
• W1963669299 countsByYear W19636692992019 @default.
• W1963669299 countsByYear W19636692992020 @default.
• W1963669299 countsByYear W19636692992021 @default.
• W1963669299 countsByYear W19636692992022 @default.
• W1963669299 countsByYear W19636692992023 @default.
• W1963669299 crossrefType "journal-article" @default.
• W1963669299 hasAuthorship W1963669299A5013866441 @default.
• W1963669299 hasAuthorship W1963669299A5014352801 @default.
• W1963669299 hasAuthorship W1963669299A5018345023 @default.
• W1963669299 hasAuthorship W1963669299A5024091596 @default.
• W1963669299 hasAuthorship W1963669299A5027835558 @default.
• W1963669299 hasAuthorship W1963669299A5027957688 @default.
• W1963669299 hasAuthorship W1963669299A5034690488 @default.
• W1963669299 hasAuthorship W1963669299A5035250882 @default.
• W1963669299 hasAuthorship W1963669299A5046904851 @default.
• W1963669299 hasAuthorship W1963669299A5049494615 @default.
• W1963669299 hasAuthorship W1963669299A5055020473 @default.
• W1963669299 hasAuthorship W1963669299A5063105528 @default.
• W1963669299 hasAuthorship W1963669299A5064378943 @default.
• W1963669299 hasConcept C126322002 @default.
• W1963669299 hasConcept C139719470 @default.
• W1963669299 hasConcept C142724271 @default.
• W1963669299 hasConcept C146304588 @default.
• W1963669299 hasConcept C162324750 @default.
• W1963669299 hasConcept C207886595 @default.
• W1963669299 hasConcept C2776867660 @default.
• W1963669299 hasConcept C2777427615 @default.
• W1963669299 hasConcept C2779134260 @default.
• W1963669299 hasConcept C2779281540 @default.
• W1963669299 hasConcept C2779483572 @default.

• next