FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963669949> ?p ?o ?g. }

• W1963669949 endingPage "137" @default.
• W1963669949 startingPage "129" @default.
• W1963669949 abstract "Toxicology and carcinogenesis studies were conducted by feeding diets containing nitrofurazone (99% pure) to groups of F344/N rats and B6C3F1 mice for 14 days, 13 wk or 2 yr. In the 14-day studies, in which doses ranged from 630 to 10,000 ppm, nitrofurazone was more toxic to mice than to rats. Accordingly, in the 13-wk studies, doses for rats ranged from 150 to 2500 ppm and for mice from 70 to 1250 ppm. At the higher doses, convulsive seizures and gonadal hypoplasia were observed in both species. Evidence of toxicity in rats also included degenerative arthropathy. For the 2-yr studies, rats were exposed to 0, 310 or 620 ppm nitrofurazone and the survival of male rats given 620 ppm was lower than that of controls (33/50, 30/50 and 20/50 in the control, 310- and 620-ppm groups, respectively). Nitrofurazone administration increased the incidences of mammary gland fibroadenomas in female rats (8/49, 36/50 and 36/50 in the control, 310- and 620-ppm groups, respectively). In male rats it was associated with a marginal increase in sebaceous gland adenomas and trichoepitheliomas of the skin, mesotheliomas of the tunica vaginalis, and tumours of the perputial gland. Nitrofurazone caused testicular degeneration (atrophy of germinal epithelium and aspermatogenesis) in rats, and degeneration of vertebral and knee articular cartilage in rats of both sexes. In mice, dietary concentrations of nitrofurazone for the 2-yr studies were 0, 150 or 310 ppm. In mice of each sex, nitrofurazone administration induced stimulus-sensitive convulsive seizures, primarily during the first year of study. In male mice, there was no evidence of any chemically-related carcinogenic effects, but there was a treatment-related decrease in survival (39/50, 31/50 and 27/50 in the control, 150- and 310-ppm groups, respectively). In female mice nitrofurazone induced ovarian lesions with increased incidences of benign mixed tumours (0/47, 17/50 and 20/50 in control, low- and high-dose groups, respectively) and granulosa cell tumours (1/47, 4/50 and 9/50 in control, low- and high-dose groups, respectively)." @default.
• W1963669949 created "2016-06-24" @default.
• W1963669949 creator A5000683146 @default.
• W1963669949 creator A5019206206 @default.
• W1963669949 creator A5022841310 @default.
• W1963669949 creator A5022989126 @default.
• W1963669949 creator A5040231643 @default.
• W1963669949 date "1989-01-01" @default.
• W1963669949 modified "2023-09-23" @default.
• W1963669949 title "Toxicity and carcinogenicity of nitrofurazone in F344/N rats and B6C3F1 mice" @default.
• W1963669949 cites W1761536971 @default.
• W1963669949 cites W1965596803 @default.
• W1963669949 cites W1965851660 @default.
• W1963669949 cites W1971777877 @default.
• W1963669949 cites W1980862224 @default.
• W1963669949 cites W1983619630 @default.
• W1963669949 cites W1983685786 @default.
• W1963669949 cites W1988173542 @default.
• W1963669949 cites W1991931561 @default.
• W1963669949 cites W1996016898 @default.
• W1963669949 cites W2012555038 @default.
• W1963669949 cites W2013380530 @default.
• W1963669949 cites W2015807534 @default.
• W1963669949 cites W2019347326 @default.
• W1963669949 cites W2021155921 @default.
• W1963669949 cites W2034174899 @default.
• W1963669949 cites W2035647761 @default.
• W1963669949 cites W2036176966 @default.
• W1963669949 cites W2047083609 @default.
• W1963669949 cites W2050329872 @default.
• W1963669949 cites W2052710617 @default.
• W1963669949 cites W2065101270 @default.
• W1963669949 cites W2074462476 @default.
• W1963669949 cites W2075924795 @default.
• W1963669949 cites W2108037853 @default.
• W1963669949 cites W2166508022 @default.
• W1963669949 cites W2333640116 @default.
• W1963669949 cites W2419256741 @default.
• W1963669949 cites W2472340789 @default.
• W1963669949 cites W4250743982 @default.
• W1963669949 doi "https://doi.org/10.1016/0278-6915(89)90008-2" @default.
• W1963669949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2714718" @default.
• W1963669949 hasPublicationYear "1989" @default.
• W1963669949 type Work @default.
• W1963669949 sameAs 1963669949 @default.
• W1963669949 citedByCount "34" @default.
• W1963669949 countsByYear W19636699492012 @default.
• W1963669949 countsByYear W19636699492013 @default.
• W1963669949 countsByYear W19636699492014 @default.
• W1963669949 countsByYear W19636699492015 @default.
• W1963669949 countsByYear W19636699492018 @default.
• W1963669949 countsByYear W19636699492019 @default.
• W1963669949 countsByYear W19636699492021 @default.
• W1963669949 countsByYear W19636699492022 @default.
• W1963669949 countsByYear W19636699492023 @default.
• W1963669949 crossrefType "journal-article" @default.
• W1963669949 hasAuthorship W1963669949A5000683146 @default.
• W1963669949 hasAuthorship W1963669949A5019206206 @default.
• W1963669949 hasAuthorship W1963669949A5022841310 @default.
• W1963669949 hasAuthorship W1963669949A5022989126 @default.
• W1963669949 hasAuthorship W1963669949A5040231643 @default.
• W1963669949 hasConcept C123765429 @default.
• W1963669949 hasConcept C126322002 @default.
• W1963669949 hasConcept C134018914 @default.
• W1963669949 hasConcept C2778466210 @default.
• W1963669949 hasConcept C2781172350 @default.
• W1963669949 hasConcept C2909802241 @default.
• W1963669949 hasConcept C29730261 @default.
• W1963669949 hasConcept C42407357 @default.
• W1963669949 hasConcept C556039675 @default.
• W1963669949 hasConcept C71924100 @default.
• W1963669949 hasConcept C86803240 @default.
• W1963669949 hasConceptScore W1963669949C123765429 @default.
• W1963669949 hasConceptScore W1963669949C126322002 @default.
• W1963669949 hasConceptScore W1963669949C134018914 @default.
• W1963669949 hasConceptScore W1963669949C2778466210 @default.
• W1963669949 hasConceptScore W1963669949C2781172350 @default.
• W1963669949 hasConceptScore W1963669949C2909802241 @default.
• W1963669949 hasConceptScore W1963669949C29730261 @default.
• W1963669949 hasConceptScore W1963669949C42407357 @default.
• W1963669949 hasConceptScore W1963669949C556039675 @default.
• W1963669949 hasConceptScore W1963669949C71924100 @default.
• W1963669949 hasConceptScore W1963669949C86803240 @default.
• W1963669949 hasIssue "2" @default.
• W1963669949 hasLocation W19636699491 @default.
• W1963669949 hasLocation W19636699492 @default.
• W1963669949 hasOpenAccess W1963669949 @default.
• W1963669949 hasPrimaryLocation W19636699491 @default.
• W1963669949 hasRelatedWork W1966504330 @default.
• W1963669949 hasRelatedWork W1966775726 @default.
• W1963669949 hasRelatedWork W1979139803 @default.
• W1963669949 hasRelatedWork W2030889776 @default.
• W1963669949 hasRelatedWork W2037631372 @default.
• W1963669949 hasRelatedWork W2040058909 @default.
• W1963669949 hasRelatedWork W2041747613 @default.
• W1963669949 hasRelatedWork W2132898409 @default.
• W1963669949 hasRelatedWork W2748952813 @default.
• W1963669949 hasRelatedWork W4249176446 @default.

• next