FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963670042> ?p ?o ?g. }

• W1963670042 endingPage "515" @default.
• W1963670042 startingPage "515" @default.
• W1963670042 abstract "Vascular endothelial growth factor (VEGF) plays a known role in regulating the tone vasomotor and maintaining blood pressure (BP). Tao and coworkers1 describe in a recent article the role of VEGF in the pathophysiology of hypertension and possible future therapeutic implications. Several studies have demonstrated the role of VEGF and endothelial viability factors. Endothelial integrity and viability is crucial in many situations, including interischemia-reperfusion, neoplasia, inflammation, perfusion of organs for transplantation, shock, and re-endothelialization of denuded surfaces.2 Endothelial dysfunction plays a major role in the development and maintenance and complications of hypertension and is a fundamental concept that explains the mechanisms by which hypertension is involved in the progression of atherosclerosis. On the other hand, nitric oxide (NO) is considered the most important endogenous vasodilator body and its deficiency is associated with elevations in BP. VEGF is a potent signaling molecule whose function is to stimulate endothelial NO synthase (eNOS) for causing release of NO vasodilatation.3 The pathways inhibition of VEGF-dependent vasodilation, such as NO, can cause capillary rarefaction with a consequent increase in tubular reabsorption of sodium and vascular resistance. The speed with which patients develop hypertension suggests that inhibition of NO plays a primary pathophysiological role. When blocks binding of VEGF to its receptor activity are inactivated, the enzyme eNOS causes reduction in NO production and increased vasoconstriction.4 For this reason, we make an effort to monitor the effects of hypertension and kidney on different VEGF inhibitors in our patients.5 However, we must not forgot that VEGF is produced by different tumors, and its production is related with aggressiveness, potential for spread, and recurrence. VEGF-A is considered the primary tumor angiogenic factor, acting together with other related molecules, such as VEGF-B, VEGF-C, VEGF-D, and placental growth factor, which, being less potent, have the ability to activate the same receptors. Furthermore, some of these molecules, such as VEGF-C and VEGF-D, not only promote angiogenesis in the normal endothelium, but also doubly affect lymphatic tumor dissemination.6 For these reasons, although this is an attractive and novel new therapeutic target, special attention must be paid to possible adverse effects on patients with hypertension and possible known or unknown tumor pathology. We should have a better knowledge about different molecular mechanisms and pleiotropic effects of VEGF and its possible adverse effects. For these reasons, we believe in the need for future clinical trials of the role of VEGF in the prevention and treatment of hypertension in this population. None." @default.
• W1963670042 created "2016-06-24" @default.
• W1963670042 creator A5016786296 @default.
• W1963670042 creator A5036894659 @default.
• W1963670042 date "2013-05-17" @default.
• W1963670042 modified "2023-09-27" @default.
• W1963670042 title "Reply to Vascular Endothelial Growth Factor: A Novel Potential Therapeutic Target for Hypertension" @default.
• W1963670042 cites W1585969896 @default.
• W1963670042 cites W2023827594 @default.
• W1963670042 cites W2028031291 @default.
• W1963670042 cites W2199292288 @default.
• W1963670042 doi "https://doi.org/10.1111/jch.12128" @default.
• W1963670042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23815543" @default.
• W1963670042 hasPublicationYear "2013" @default.
• W1963670042 type Work @default.
• W1963670042 sameAs 1963670042 @default.
• W1963670042 citedByCount "1" @default.
• W1963670042 countsByYear W19636700422014 @default.
• W1963670042 crossrefType "journal-article" @default.
• W1963670042 hasAuthorship W1963670042A5016786296 @default.
• W1963670042 hasAuthorship W1963670042A5036894659 @default.
• W1963670042 hasBestOaLocation W19636700421 @default.
• W1963670042 hasConcept C120770815 @default.
• W1963670042 hasConcept C126322002 @default.
• W1963670042 hasConcept C134018914 @default.
• W1963670042 hasConcept C146285616 @default.
• W1963670042 hasConcept C15215337 @default.
• W1963670042 hasConcept C167734588 @default.
• W1963670042 hasConcept C2777025900 @default.
• W1963670042 hasConcept C2777622882 @default.
• W1963670042 hasConcept C2778326061 @default.
• W1963670042 hasConcept C2779961880 @default.
• W1963670042 hasConcept C2780972559 @default.
• W1963670042 hasConcept C519581460 @default.
• W1963670042 hasConcept C57190642 @default.
• W1963670042 hasConcept C71924100 @default.
• W1963670042 hasConcept C84393581 @default.
• W1963670042 hasConcept C98274493 @default.
• W1963670042 hasConceptScore W1963670042C120770815 @default.
• W1963670042 hasConceptScore W1963670042C126322002 @default.
• W1963670042 hasConceptScore W1963670042C134018914 @default.
• W1963670042 hasConceptScore W1963670042C146285616 @default.
• W1963670042 hasConceptScore W1963670042C15215337 @default.
• W1963670042 hasConceptScore W1963670042C167734588 @default.
• W1963670042 hasConceptScore W1963670042C2777025900 @default.
• W1963670042 hasConceptScore W1963670042C2777622882 @default.
• W1963670042 hasConceptScore W1963670042C2778326061 @default.
• W1963670042 hasConceptScore W1963670042C2779961880 @default.
• W1963670042 hasConceptScore W1963670042C2780972559 @default.
• W1963670042 hasConceptScore W1963670042C519581460 @default.
• W1963670042 hasConceptScore W1963670042C57190642 @default.
• W1963670042 hasConceptScore W1963670042C71924100 @default.
• W1963670042 hasConceptScore W1963670042C84393581 @default.
• W1963670042 hasConceptScore W1963670042C98274493 @default.
• W1963670042 hasIssue "7" @default.
• W1963670042 hasLocation W19636700421 @default.
• W1963670042 hasLocation W19636700422 @default.
• W1963670042 hasLocation W19636700423 @default.
• W1963670042 hasOpenAccess W1963670042 @default.
• W1963670042 hasPrimaryLocation W19636700421 @default.
• W1963670042 hasRelatedWork W2028343319 @default.
• W1963670042 hasRelatedWork W2035210780 @default.
• W1963670042 hasRelatedWork W2038545399 @default.
• W1963670042 hasRelatedWork W2050169039 @default.
• W1963670042 hasRelatedWork W2413511430 @default.
• W1963670042 hasRelatedWork W2740203203 @default.
• W1963670042 hasRelatedWork W2890630804 @default.
• W1963670042 hasRelatedWork W2896893594 @default.
• W1963670042 hasRelatedWork W4307462565 @default.
• W1963670042 hasRelatedWork W1927863502 @default.
• W1963670042 hasVolume "15" @default.
• W1963670042 isParatext "false" @default.
• W1963670042 isRetracted "false" @default.
• W1963670042 magId "1963670042" @default.
• W1963670042 workType "article" @default.