FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963670498> ?p ?o ?g. }

• W1963670498 endingPage "785" @default.
• W1963670498 startingPage "779" @default.
• W1963670498 abstract "Pro-inflammatory mediators, such as nitric oxide (NO), prostaglandin E(2) (PGE(2)), and several cytokines (tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6) are responsible for central nervous system (CNS) injuries that include ischemia, Alzheimer's disease, and neural death. Inhibition of these pro-inflammatory mediators would be an effective therapy to reduce the progression of neurodegenerative diseases. In this study, we examined the anti-inflammatory effects of a human prothrombin fragment-2-derived peptide, NSA9 (NSAVQLVEN), on the production of pro-inflammatory mediators in lipopolysaccharide (LPS)-activated brain microglia. NSA9 significantly inhibited the release of NO, PGE(2), and pro-inflammatory cytokines in a dose-dependent manner. Furthermore, NSA9 reduced the expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 mRNA and protein, which control the production of NO and PGE(2), respectively. Moreover, NSA9 suppressed the LPS-induced nuclear translocation and activation of nuclear factor-kappaB (NF-kappaB). These results suggest that NSA9 strongly inhibits the pro-inflammatory responses of microglia through the modulation of NF-kappaB activity." @default.
• W1963670498 created "2016-06-24" @default.
• W1963670498 creator A5015230939 @default.
• W1963670498 creator A5017016273 @default.
• W1963670498 creator A5023985663 @default.
• W1963670498 date "2008-04-01" @default.
• W1963670498 modified "2023-09-27" @default.
• W1963670498 title "Anti-inflammatory effect of a human prothrombin fragment-2-derived peptide, NSA9, in EOC2 microglia" @default.
• W1963670498 cites W1490228662 @default.
• W1963670498 cites W1576660441 @default.
• W1963670498 cites W1591881963 @default.
• W1963670498 cites W1670607653 @default.
• W1963670498 cites W1929363980 @default.
• W1963670498 cites W1976326847 @default.
• W1963670498 cites W1978525572 @default.
• W1963670498 cites W1985221375 @default.
• W1963670498 cites W1985407614 @default.
• W1963670498 cites W1998135877 @default.
• W1963670498 cites W2003321649 @default.
• W1963670498 cites W2003437276 @default.
• W1963670498 cites W2004465286 @default.
• W1963670498 cites W2009639401 @default.
• W1963670498 cites W2009787256 @default.
• W1963670498 cites W2014712705 @default.
• W1963670498 cites W2015903618 @default.
• W1963670498 cites W2016232584 @default.
• W1963670498 cites W2021626693 @default.
• W1963670498 cites W2023235828 @default.
• W1963670498 cites W2038197749 @default.
• W1963670498 cites W2039453997 @default.
• W1963670498 cites W2046090968 @default.
• W1963670498 cites W2049618347 @default.
• W1963670498 cites W2052650759 @default.
• W1963670498 cites W2056351034 @default.
• W1963670498 cites W2060084413 @default.
• W1963670498 cites W2064594022 @default.
• W1963670498 cites W2075119261 @default.
• W1963670498 cites W2084121027 @default.
• W1963670498 cites W2100123567 @default.
• W1963670498 cites W2135482947 @default.
• W1963670498 cites W2137850881 @default.
• W1963670498 cites W2146957909 @default.
• W1963670498 cites W2148256905 @default.
• W1963670498 cites W4319425401 @default.
• W1963670498 doi "https://doi.org/10.1016/j.bbrc.2008.01.142" @default.
• W1963670498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18261978" @default.
• W1963670498 hasPublicationYear "2008" @default.
• W1963670498 type Work @default.
• W1963670498 sameAs 1963670498 @default.
• W1963670498 citedByCount "18" @default.
• W1963670498 countsByYear W19636704982013 @default.
• W1963670498 countsByYear W19636704982015 @default.
• W1963670498 countsByYear W19636704982017 @default.
• W1963670498 countsByYear W19636704982019 @default.
• W1963670498 countsByYear W19636704982022 @default.
• W1963670498 crossrefType "journal-article" @default.
• W1963670498 hasAuthorship W1963670498A5015230939 @default.
• W1963670498 hasAuthorship W1963670498A5017016273 @default.
• W1963670498 hasAuthorship W1963670498A5023985663 @default.
• W1963670498 hasConcept C134018914 @default.
• W1963670498 hasConcept C164027704 @default.
• W1963670498 hasConcept C17991360 @default.
• W1963670498 hasConcept C185592680 @default.
• W1963670498 hasConcept C203014093 @default.
• W1963670498 hasConcept C2776914184 @default.
• W1963670498 hasConcept C2777198256 @default.
• W1963670498 hasConcept C2777622882 @default.
• W1963670498 hasConcept C2777956040 @default.
• W1963670498 hasConcept C2778690821 @default.
• W1963670498 hasConcept C2778754761 @default.
• W1963670498 hasConcept C2779830541 @default.
• W1963670498 hasConcept C519581460 @default.
• W1963670498 hasConcept C529278444 @default.
• W1963670498 hasConcept C71924100 @default.
• W1963670498 hasConcept C74172505 @default.
• W1963670498 hasConcept C87753298 @default.
• W1963670498 hasConcept C98274493 @default.
• W1963670498 hasConceptScore W1963670498C134018914 @default.
• W1963670498 hasConceptScore W1963670498C164027704 @default.
• W1963670498 hasConceptScore W1963670498C17991360 @default.
• W1963670498 hasConceptScore W1963670498C185592680 @default.
• W1963670498 hasConceptScore W1963670498C203014093 @default.
• W1963670498 hasConceptScore W1963670498C2776914184 @default.
• W1963670498 hasConceptScore W1963670498C2777198256 @default.
• W1963670498 hasConceptScore W1963670498C2777622882 @default.
• W1963670498 hasConceptScore W1963670498C2777956040 @default.
• W1963670498 hasConceptScore W1963670498C2778690821 @default.
• W1963670498 hasConceptScore W1963670498C2778754761 @default.
• W1963670498 hasConceptScore W1963670498C2779830541 @default.
• W1963670498 hasConceptScore W1963670498C519581460 @default.
• W1963670498 hasConceptScore W1963670498C529278444 @default.
• W1963670498 hasConceptScore W1963670498C71924100 @default.
• W1963670498 hasConceptScore W1963670498C74172505 @default.
• W1963670498 hasConceptScore W1963670498C87753298 @default.
• W1963670498 hasConceptScore W1963670498C98274493 @default.
• W1963670498 hasIssue "3" @default.
• W1963670498 hasLocation W19636704981 @default.
• W1963670498 hasLocation W19636704982 @default.

• next