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- W1963676711 abstract "In 1912, Bowen 1 reported a study of two cases of chronic atypical epithelial proliferation to which he gave designation of precancerous dermatosis. Since then, this condition has been subject of investigation by many workers, including Darier, 2 Highman, 3 Fraser, 4 Wise 5 and others. A great deal has been written regarding its exact status in field of neoplastic growths, but most dermatopathologists are in accord with Fraser, who believes that the cellular changes constituting this lesion are, from beginning, those generally considered as characteristic of malignancy. He pointed out that pathologically the cells in Bowen lesion have already undergone changes of malignant neoplasia, and for this reason lesion should be classified as an intraepidermal carcinoma. As Wise 5 has pointed out, a definite diagnosis of Bowen's disease cannot be made on clinical evidence, but only on characteristic microscopic" @default.
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- W1963676711 date "1932-12-01" @default.
- W1963676711 modified "2023-09-25" @default.
- W1963676711 title "BOWEN'S PRECANCEROUS DERMATOSIS AND MULTIPLE BENIGN SUPERFICIAL EPITHELIOMA" @default.
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- W1963676711 doi "https://doi.org/10.1001/archderm.1932.01450031054011" @default.
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