FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963679461> ?p ?o ?g. }

• W1963679461 endingPage "51" @default.
• W1963679461 startingPage "41" @default.
• W1963679461 abstract "D. melanogaster is an excellent animal model to study how the circadian (≅24-h) timing system and sleep regulate daily wake-sleep cycles. Splicing of a temperature-sensitive 3'-terminal intron (termed dmpi8) from the circadian clock gene period (per) regulates the distribution of daily activity in Drosophila. The role of dmpi8 splicing on daily behavior was further evaluated by analyzing sleep.Transgenic flies of the same genetic background but expressing either a wild-type recombinant per gene or one where the efficiency of dmpi8 splicing was increased were exposed to different temperatures in daily light-dark cycles and sleep parameters measured. In addition, transgenic flies were briefly exposed to a variety of sensory-mediated stimuli to measure arousal responses.Surprisingly, we show that the effect of dmpi8 splicing on daytime activity levels does not involve a circadian role for per but is linked to adjustments in sensory-dependent arousal and sleep behavior. Genetically altered flies with high dmpi8 splicing efficiency remain aroused longer following short treatments with light and non-photic cues such as mechanical stimulation.We propose that the thermal regulation of dmpi8 splicing acts as a temperature-calibrated rheostat in a novel arousal mechanism, so that on warm days the inefficient splicing of the dmpi8 intron triggers an increase in quiescence by decreasing sensory-mediated arousal, thus ensuring flies minimize being active during the hot midday sun despite the presence of light in the environment, which is usually a strong arousal cue for diurnal animals." @default.
• W1963679461 created "2016-06-24" @default.
• W1963679461 creator A5059783595 @default.
• W1963679461 creator A5084382035 @default.
• W1963679461 date "2015-01-01" @default.
• W1963679461 modified "2023-10-14" @default.
• W1963679461 title "A Novel Pathway for Sensory-Mediated Arousal Involves Splicing of an Intron in the<i>period</i>Clock Gene" @default.
• W1963679461 cites W1522365127 @default.
• W1963679461 cites W1523081572 @default.
• W1963679461 cites W1569437915 @default.
• W1963679461 cites W1599101054 @default.
• W1963679461 cites W1605372070 @default.
• W1963679461 cites W1968410906 @default.
• W1963679461 cites W1976561113 @default.
• W1963679461 cites W1985471830 @default.
• W1963679461 cites W1987829359 @default.
• W1963679461 cites W1998371106 @default.
• W1963679461 cites W1999182669 @default.
• W1963679461 cites W1999568022 @default.
• W1963679461 cites W1999819966 @default.
• W1963679461 cites W2020159596 @default.
• W1963679461 cites W2025857254 @default.
• W1963679461 cites W2038911675 @default.
• W1963679461 cites W2044221124 @default.
• W1963679461 cites W2048308036 @default.
• W1963679461 cites W2052752000 @default.
• W1963679461 cites W2054591837 @default.
• W1963679461 cites W2056213320 @default.
• W1963679461 cites W2056240302 @default.
• W1963679461 cites W2060660675 @default.
• W1963679461 cites W2072126324 @default.
• W1963679461 cites W2073036589 @default.
• W1963679461 cites W2074377442 @default.
• W1963679461 cites W2083495311 @default.
• W1963679461 cites W2086967162 @default.
• W1963679461 cites W2091287207 @default.
• W1963679461 cites W2101315076 @default.
• W1963679461 cites W2104156279 @default.
• W1963679461 cites W2106017969 @default.
• W1963679461 cites W2113408475 @default.
• W1963679461 cites W2119706891 @default.
• W1963679461 cites W2127186571 @default.
• W1963679461 cites W2139967456 @default.
• W1963679461 cites W2140173884 @default.
• W1963679461 cites W2140807864 @default.
• W1963679461 cites W2145517507 @default.
• W1963679461 cites W2146575770 @default.
• W1963679461 cites W2153041353 @default.
• W1963679461 cites W2160441222 @default.
• W1963679461 cites W2163074265 @default.
• W1963679461 cites W2346964101 @default.
• W1963679461 doi "https://doi.org/10.5665/sleep.4322" @default.
• W1963679461 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4262954" @default.
• W1963679461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25325457" @default.
• W1963679461 hasPublicationYear "2015" @default.
• W1963679461 type Work @default.
• W1963679461 sameAs 1963679461 @default.
• W1963679461 citedByCount "18" @default.
• W1963679461 countsByYear W19636794612015 @default.
• W1963679461 countsByYear W19636794612016 @default.
• W1963679461 countsByYear W19636794612017 @default.
• W1963679461 countsByYear W19636794612018 @default.
• W1963679461 countsByYear W19636794612019 @default.
• W1963679461 countsByYear W19636794612020 @default.
• W1963679461 countsByYear W19636794612021 @default.
• W1963679461 countsByYear W19636794612022 @default.
• W1963679461 crossrefType "journal-article" @default.
• W1963679461 hasAuthorship W1963679461A5059783595 @default.
• W1963679461 hasAuthorship W1963679461A5084382035 @default.
• W1963679461 hasBestOaLocation W19636794611 @default.
• W1963679461 hasConcept C102230213 @default.
• W1963679461 hasConcept C104317684 @default.
• W1963679461 hasConcept C111919701 @default.
• W1963679461 hasConcept C121332964 @default.
• W1963679461 hasConcept C121446783 @default.
• W1963679461 hasConcept C126322002 @default.
• W1963679461 hasConcept C134018914 @default.
• W1963679461 hasConcept C169760540 @default.
• W1963679461 hasConcept C194583182 @default.
• W1963679461 hasConcept C24890656 @default.
• W1963679461 hasConcept C2775841894 @default.
• W1963679461 hasConcept C2779320081 @default.
• W1963679461 hasConcept C2780104201 @default.
• W1963679461 hasConcept C2781291010 @default.
• W1963679461 hasConcept C36823959 @default.
• W1963679461 hasConcept C36951298 @default.
• W1963679461 hasConcept C38606739 @default.
• W1963679461 hasConcept C41008148 @default.
• W1963679461 hasConcept C522805319 @default.
• W1963679461 hasConcept C54355233 @default.
• W1963679461 hasConcept C54458228 @default.
• W1963679461 hasConcept C67705224 @default.
• W1963679461 hasConcept C71924100 @default.
• W1963679461 hasConcept C86803240 @default.
• W1963679461 hasConcept C94487597 @default.
• W1963679461 hasConcept C94671646 @default.
• W1963679461 hasConcept C95444343 @default.
• W1963679461 hasConceptScore W1963679461C102230213 @default.

• next