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- W1963679884 abstract "Nine hours after ethionine administration, an inhibition of RNA synthesis in vivo is detectable (about 80%). In vitro, purified nuclei have a decreased capacity for incorporating labeled precursor into acid-insoluble material, and both RNA polymerase I + III and RNA polymerase II activities are inhibited, thus confirming the effects of ethionine on RNA synthesis (for a review, see Farber, E. (1971) Annu. Rev. Pharmacol.11, 71–96). It is further reported that solubilized RNA polymerases from liver nuclei of ethionine-treated rats have decreased activities with respect to polymerases from control animals. Chromatin but not deproteinized chromatin from livers of treated rats had a reduced template activity when assayed with partially purified RNA polymerase II from normal rat liver." @default.
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- W1963679884 date "1977-12-01" @default.
- W1963679884 modified "2023-10-16" @default.
- W1963679884 title "Aspects of the inhibition of RNA synthesis by ethionine in rat liver" @default.
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- W1963679884 doi "https://doi.org/10.1016/0014-4800(77)90011-9" @default.
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