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- W1963680835 abstract "Abstract FSH, oestrone (E1), 17β-oestradiol (E2) and androstenedione (A) were determined in 250 healthy pre- and post-menopausal women, with ages ranging from 40 to 78 yr. These hormone levels were not found to have changed significantly in women of this stable, post-menopausal phase after the age of 54. The results found in this group of women (n = 107), who now range between the ages of 55 and 78, were compared with results from two groups of women who were found to have gynaecological disorders. The first group consisted of 45 women with post-menopausal bleeding without endometrial carcinoma. The second group consisted of 38 women with post-menopausal bleeding and endometrial carcinoma. FSH was determined by double-antibody radioimmunoassay. El, E2 and A were fractionated chromatographically after extraction with ether and determined radioimmunologically. The data were analysed using the Kruskal—Wallis test and the Wilcoxon test. When comparing the measurement of hormone levels in the healthy group of women with that of women with post-menopausal bleeding without endometrial carcinoma, no differences were found. However, in the group of women with post-menopausal bleeding and endometrial carcinoma, lower levels of FSH and E2 and increases in the E1/E2 ratio were found; both changes were statistically significant. The slight increase in E1 and A found in these women was not significant. Any changes which occur in the hormone levels of women with endometrial carcinoma may indicate a correlation between hormones and the onset of endometrial carcinoma." @default.
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- W1963680835 date "1981-12-01" @default.
- W1963680835 modified "2023-09-27" @default.
- W1963680835 title "Hormone levels in healthy post-menopausal women and in women with post-menopausal bleeding with or without endometrial carcinoma" @default.
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- W1963680835 doi "https://doi.org/10.1016/0378-5122(81)90040-2" @default.
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