FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963685478> ?p ?o ?g. }

• W1963685478 endingPage "4997" @default.
• W1963685478 startingPage "4986" @default.
• W1963685478 abstract "Cellular metastasis is the most detrimental step in carcinoma disease progression, yet the mechanisms that regulate this process are poorly understood. CXCL12 and its receptor CXCR4 are co-expressed in several tissues and cell types throughout the body and play essential roles in development. Disruption of either gene causes embryonic lethality due to similar defects. Post-natally, CXCL12 signaling has a wide range of effects on CXCR4-expressing cells, including the directed migration of leukocytes, lymphocytes and hematopoietic stem cells. Recently, this signaling axis has also been described as an important regulator of directed carcinoma cell metastasis. We show herein that while CXCR4 expression remains consistent, constitutive colonic epithelial expression of CXCL12 is silenced by DNA hypermethylation in primary colorectal carcinomas as well as colorectal carcinoma-derived cell lines. Inhibition of DNA methyltransferase (Dnmt) enzymes with 5-aza-2′-deoxycytidine or genetic ablation of both Dnmt1 and Dnmt3b prevented promoter methylation and restored CXCL12 expression. Re-expression of functional, endogenous CXCL12 in colorectal carcinoma cells dramatically reduced metastatic tumor formation in mice, as well as foci formation in soft agar. Decreased metastasis was correlated with increased caspase activity in cells re-expressing CXCL12. These data constitute the unique observation that silencing CXCL12 within colonic carcinoma cells greatly enhances their metastatic potential." @default.
• W1963685478 created "2016-06-24" @default.
• W1963685478 creator A5022105097 @default.
• W1963685478 creator A5046248413 @default.
• W1963685478 creator A5048615239 @default.
• W1963685478 creator A5081128645 @default.
• W1963685478 creator A5090812461 @default.
• W1963685478 creator A5090843213 @default.
• W1963685478 date "2006-03-27" @default.
• W1963685478 modified "2023-09-27" @default.
• W1963685478 title "Silencing of epithelial CXCL12 expression by DNA hypermethylation promotes colonic carcinoma metastasis" @default.
• W1963685478 cites W1485239984 @default.
• W1963685478 cites W1522855936 @default.
• W1963685478 cites W1965207164 @default.
• W1963685478 cites W1967616608 @default.
• W1963685478 cites W1968263601 @default.
• W1963685478 cites W1974132609 @default.
• W1963685478 cites W1982543774 @default.
• W1963685478 cites W1989421786 @default.
• W1963685478 cites W1994465394 @default.
• W1963685478 cites W2001258296 @default.
• W1963685478 cites W2003625711 @default.
• W1963685478 cites W2005535987 @default.
• W1963685478 cites W2010638326 @default.
• W1963685478 cites W2017515560 @default.
• W1963685478 cites W2018984903 @default.
• W1963685478 cites W2037905760 @default.
• W1963685478 cites W2062053156 @default.
• W1963685478 cites W2065575295 @default.
• W1963685478 cites W2075971846 @default.
• W1963685478 cites W2077781719 @default.
• W1963685478 cites W2081769332 @default.
• W1963685478 cites W2083612980 @default.
• W1963685478 cites W2084704534 @default.
• W1963685478 cites W2087198289 @default.
• W1963685478 cites W2093188241 @default.
• W1963685478 cites W2096142571 @default.
• W1963685478 cites W2104672248 @default.
• W1963685478 cites W2106756765 @default.
• W1963685478 cites W2107038650 @default.
• W1963685478 cites W2107679332 @default.
• W1963685478 cites W2118397294 @default.
• W1963685478 cites W2133260339 @default.
• W1963685478 cites W2133462041 @default.
• W1963685478 cites W2139122477 @default.
• W1963685478 cites W2141817304 @default.
• W1963685478 cites W2144805183 @default.
• W1963685478 cites W2145750252 @default.
• W1963685478 cites W2156323704 @default.
• W1963685478 cites W2158294445 @default.
• W1963685478 cites W2161199652 @default.
• W1963685478 cites W2163572306 @default.
• W1963685478 cites W2165521277 @default.
• W1963685478 cites W2171248814 @default.
• W1963685478 cites W2227704724 @default.
• W1963685478 cites W2277729681 @default.
• W1963685478 doi "https://doi.org/10.1038/sj.onc.1209505" @default.
• W1963685478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4610155" @default.
• W1963685478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16568088" @default.
• W1963685478 hasPublicationYear "2006" @default.
• W1963685478 type Work @default.
• W1963685478 sameAs 1963685478 @default.
• W1963685478 citedByCount "130" @default.
• W1963685478 countsByYear W19636854782012 @default.
• W1963685478 countsByYear W19636854782013 @default.
• W1963685478 countsByYear W19636854782014 @default.
• W1963685478 countsByYear W19636854782015 @default.
• W1963685478 countsByYear W19636854782016 @default.
• W1963685478 countsByYear W19636854782017 @default.
• W1963685478 countsByYear W19636854782018 @default.
• W1963685478 countsByYear W19636854782019 @default.
• W1963685478 countsByYear W19636854782020 @default.
• W1963685478 countsByYear W19636854782021 @default.
• W1963685478 countsByYear W19636854782022 @default.
• W1963685478 countsByYear W19636854782023 @default.
• W1963685478 crossrefType "journal-article" @default.
• W1963685478 hasAuthorship W1963685478A5022105097 @default.
• W1963685478 hasAuthorship W1963685478A5046248413 @default.
• W1963685478 hasAuthorship W1963685478A5048615239 @default.
• W1963685478 hasAuthorship W1963685478A5081128645 @default.
• W1963685478 hasAuthorship W1963685478A5090812461 @default.
• W1963685478 hasAuthorship W1963685478A5090843213 @default.
• W1963685478 hasBestOaLocation W19636854781 @default.
• W1963685478 hasConcept C104317684 @default.
• W1963685478 hasConcept C119056186 @default.
• W1963685478 hasConcept C121608353 @default.
• W1963685478 hasConcept C150194340 @default.
• W1963685478 hasConcept C175211621 @default.
• W1963685478 hasConcept C190727270 @default.
• W1963685478 hasConcept C2779013556 @default.
• W1963685478 hasConcept C2779979206 @default.
• W1963685478 hasConcept C502942594 @default.
• W1963685478 hasConcept C54355233 @default.
• W1963685478 hasConcept C86803240 @default.
• W1963685478 hasConceptScore W1963685478C104317684 @default.
• W1963685478 hasConceptScore W1963685478C119056186 @default.
• W1963685478 hasConceptScore W1963685478C121608353 @default.
• W1963685478 hasConceptScore W1963685478C150194340 @default.

• next