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• W1963695673 abstract "Acs2p is one of two acetyl-coenzyme A synthetases in Saccharomyces cerevisiae. We have prepared and characterized a monoclonal antibody specific for Acs2p and find that Acs2p is localized primarily to the nucleus, including the nucleolus, with a minor amount in the cytosol. We find that Acs2p is required for replicative longevity: an acs2∆ strain has a reduced replicative life span compared to wild-type and acs1∆ strains. Furthermore, replicatively aged acs2∆ cells contain elevated levels of extrachromosomal rDNA circles, and silencing at the rDNA locus is impaired in an acs2∆ strain. These findings indicate that Acs2p-mediated synthesis of acetyl-CoA in the nucleus functions to promote rDNA silencing and replicative longevity in yeast." @default.
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• W1963695673 date "2009-07-19" @default.
• W1963695673 modified "2023-10-12" @default.
• W1963695673 title "Acetyl-coenzyme A synthetase 2 is a nuclear protein required for replicative longevity in Saccharomyces cerevisiae" @default.
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• W1963695673 doi "https://doi.org/10.1007/s11010-009-0209-z" @default.
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