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- W1963701617 abstract "Abstract 1. Rats were fed fat free diet for 5 weeks to produce essential fatty acid deficiency. At the end of the feeding period rats were injected by 3-methylcholanthrene (MC) or Clophen A-50 (A-50) to find out the effect of dietary fat deficiency on the inducibility of drug metabolizing enzymes. 2. Fat free diet decreased microsomal protein content and the essential fatty acid content of microsomal phospholipids both in induced and control rats and consequently also the activities of microsomal drug metabolizing enzymes. Both MC and A-50 enhanced microsomal cytochrome P-450 content and the aryl hydrocarbon hydroxylase and UDP glucuronosyltransferase activities more in rats fed conventional diet than in rats fed fat free diet. 3. When the efficiency of the inducers was determined by comparing the increase in the enzyme activities to respective controls fed the same diet the inducibility was at least as high in rats fed fat free diet as in those fed conventional diet. 4. Dietary lipids do not affect the inducibility of the enzymes but rather contribute to the activities by regulating the lipoidal microenvironment of the membrane-bound enzymes." @default.
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- W1963701617 date "1978-01-01" @default.
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- W1963701617 title "Inducibility of hepatic drug metabolizing enzymes during fat deficiency" @default.
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- W1963701617 doi "https://doi.org/10.1016/0306-3623(78)90079-4" @default.
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