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- W1963701641 abstract "Objective: The aim of this study was to determine whether the p53 codon 72 polymorphism is associated with susceptibility to endometriosis.Methods: A meta-analysis was conducted on the associations between the p53 codon 72 polymorphism and endometriosis using 1) allele contrast, 2) a recessive model, 3) a dominant model, and 4) homozygote contrast.Results: Nine studies involving 1,803 patients and 2,006 controls were considered in the meta-analysis. Meta-analysis of the p53 polymorphism showed no association between endometriosis and the p53 C allele (odds ratio (OR) = 1.087, 95% confidence interval (CI) = 0.921–1.282, p = 0.323). Stratification by ethnicity indicated no association between the p53 C allele and endometriosis in Europeans and Latin Americans. However, a significant association was found between the p53 C allele and endometriosis in East Asians (OR = 1.405, 95% CI = 1.065–1.854, p = 0.016). Furthermore, association was found between the p53 polymorphism and endometriosis in East Asians using the dominant model (OR = 2.046, 95% CI = 1.123–3.730, p = 0.019).Conclusions: This meta-analysis demonstrates that the p53 codon 72 polymorphism may be associated with susceptibility to endometriosis in East Asians, but not in Europeans and Latin Americans." @default.
- W1963701641 created "2016-06-24" @default.
- W1963701641 creator A5047843177 @default.
- W1963701641 creator A5058070113 @default.
- W1963701641 date "2014-07-07" @default.
- W1963701641 modified "2023-10-16" @default.
- W1963701641 title "A Meta-analysis of the Association between p53 Codon 72 Polymorphism and Susceptibility to Endometriosis" @default.
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- W1963701641 doi "https://doi.org/10.3109/08820139.2013.833623" @default.
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