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- W1963704808 abstract "A double-blind, placebo-controlled, cross-over clinical trial was performed to assess the effect of betahistine hydrochloride (Serc) in Ménière's disease. The diagnosis was based on paroxysmal attacks of rotational vertigo, with tinnitus, and a fluctuating sensori-neural deafness, together with the results of auditory and vestigular tests. Twenty-eight patients were admitted to the trial over 3 years. Twenty-two patients completed the trial. In total, they received betahistine 32 mg daily, for a period of 16 weeks, and placebo also for the same length of time, preceded in every case by a 4-week pre-treatment period. Daily symptom score cards were kept. There was a statistically significant improvement in favour of the drug with regard to vertigo, tinnitus and deafness. Vertigo was the most responsive symptom. No adverse reactions were observed." @default.
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- W1963704808 date "1976-08-01" @default.
- W1963704808 modified "2023-09-30" @default.
- W1963704808 title "Betahistine hydrochloride in Méniére's disease" @default.
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- W1963704808 doi "https://doi.org/10.1136/pgmj.52.610.501" @default.
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